Primary ovarian insufficiencyGene: WRN
POI as with any premature ageing syndrome is expected. WRN patients may be identified in other cohorts, but what might be interesting is whether digenic inheritance plays a role in POI, and therefore these rare heterozygous variants may be of more importance.
Created: 9 Jun 2017, 4:29 p.m.
Comment when marking as ready: Marked as red as patients with Werner Syndrome would be expected to be recruited under a different disease category given the syndromic phenotype
Created: 30 May 2017, 1:32 p.m.
POI can be a feature of Werner syndrome
Created: 26 May 2017, 11:07 a.m.
Promoting to Version 1 on 31-05-2017, after internal curation and review.
This gene has been classified as Red List (Low Evidence).
WRN was added to Early onset familial premature ovarian insufficiencypanel. Sources: Literature
WRN was created by arianna