Primary ovarian insufficiency

Gene: WRN

Red List (low evidence)

WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 17 panels

2 reviews

Louise IZATT (GSTT Clinical Genetics Service)

Red List (low evidence)

POI as with any premature ageing syndrome is expected. WRN patients may be identified in other cohorts, but what might be interesting is whether digenic inheritance plays a role in POI, and therefore these rare heterozygous variants may be of more importance.
Created: 9 Jun 2017, 4:29 p.m.

Arianna Tucci (Genomics England Curator)

Comment when marking as ready: Marked as red as patients with Werner Syndrome would be expected to be recruited under a different disease category given the syndromic phenotype
Created: 30 May 2017, 1:32 p.m.
POI can be a feature of Werner syndrome
Created: 26 May 2017, 11:07 a.m.

History Filter Activity

31 May 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoting to Version 1 on 31-05-2017, after internal curation and review.

30 May 2017, Gel status: 1

Gene classified by Genomics England curator

Arianna Tucci (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

25 May 2017, Gel status: 0

Added New Source

Arianna Tucci (Genomics England Curator)

WRN was added to Early onset familial premature ovarian insufficiencypanel. Sources: Literature

25 May 2017, Gel status: 0

Created

Arianna Tucci (Genomics England Curator)

WRN was created by arianna