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  3. AGT
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Unexplained kidney failure in young people

Gene: AGT

Green List (high evidence)
AGT (angiotensinogen)
EnsemblGeneIds (GRCh38): ENSG00000135744
EnsemblGeneIds (GRCh37): ENSG00000135744
OMIM: 106150, Gene2Phenotype
AGT is in 8 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. At least three variants reported
Created: 4 Aug 2016, 10:05 a.m.
Comment on phenotypes: Also associated with {Hypertension, essential, susceptibility to} 145500;{Preeclampsia, susceptibility to}
Created: 4 Aug 2016, 10:05 a.m.
Created: 4 Aug 2016, 10:05 a.m.

Panel version: 0.153

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • UKGTN
  • Radboud University Medical Center, Nijmegen
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • Renal tubular dysgenesis, 267430
OMIM
106150
Clinvar variants
Variants in AGT
Penetrance
Complete
Panels with this gene

History Filter Activity

17 Aug 2016, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

Promoted to version 1 17th August 2016

4 Aug 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

4 Aug 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for AGT were set to Renal tubular dysgenesis, 267430

4 Aug 2016, Gel status: 4

Upload gene information

Sarah Leigh (Genomics England Curator)

AGT was added to Unexplained kidney failure in young peoplepanel. Sources: UKGTN

26 Jun 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for AGT were set to Renal tubular dysgenesis, 267430

18 May 2016, Gel status: 4

Added New Source

Sarah Leigh (Genomics England Curator)

AGT was added to Unexplained kidney failure in young peoplepanel. Sources: Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Expert Review Green

18 May 2016, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

AGT was created by sleigh