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  2. Unexplained kidney failure in young people
  3. LRIG2
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Unexplained kidney failure in young people

Gene: LRIG2

Green List (high evidence)
LRIG2 (leucine rich repeats and immunoglobulin like domains 2)
EnsemblGeneIds (GRCh38): ENSG00000198799
EnsemblGeneIds (GRCh37): ENSG00000198799
OMIM: 608869, Gene2Phenotype
LRIG2 is in 6 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM and G2P. At least four variants reported
Created: 4 Aug 2016, 2:14 p.m.
Comment on publications: 23313374
Created: 4 Aug 2016, 2:14 p.m.
Created: 4 Aug 2016, 2:14 p.m.

Panel version: 0.219

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Radboud University Medical Center, Nijmegen
  • Expert Review
Phenotypes
  • Urofacial syndrome 2 615112
OMIM
608869
Clinvar variants
Variants in LRIG2
Penetrance
Complete
Publications
  • Stuart HM, Roberts NA, Bergu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson J, Mermerkaya M, Silay MS, Lewis MA, Olondriz BO, Gener B, Beetz C, Varga RE, G lp nar O, S er E, Yal nkaya F, G c k A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS, Newman WG. LRIG2 mutations cause urofacial syndrome. Am J Hum Genet 92:259-264, 2013.
Panels with this gene

History Filter Activity

30 Jan 2019, Gel status: 3

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Phenotypes for gene: LRIG2 were changed from Urofacial syndrome 2 615112 to Urofacial syndrome 2 615112

17 Aug 2016, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

Promoted to version 1 17th August 2016

4 Aug 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

4 Aug 2016, Gel status: 4

Set publications

Sarah Leigh (Genomics England Curator)

Publications for LRIG2 were set to Stuart HM, Roberts NA, Bergu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson J, Mermerkaya M, Silay MS, Lewis MA, Olondriz BO, Gener B, Beetz C, Varga RE, G lp nar O, S er E, Yal nkaya F, G c k A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS, Newman WG. LRIG2 mutations cause urofacial syndrome. Am J Hum Genet 92:259-264, 2013.

4 Aug 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for LRIG2 were set to Urofacial syndrome 2 615112

4 Aug 2016, Gel status: 4

Upload gene information

Sarah Leigh (Genomics England Curator)

LRIG2 was added to Unexplained kidney failure in young peoplepanel. Sources: Radboud University Medical Center, Nijmegen

27 Jun 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for LRIG2 were set to Urofacial syndrome 2 615112; Congenital bladder disease: dyssynergic, high pressure bladder.

18 May 2016, Gel status: 4

Added New Source

Sarah Leigh (Genomics England Curator)

LRIG2 was added to Unexplained kidney failure in young peoplepanel. Sources: Expert Review,Expert Review Green

18 May 2016, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

LRIG2 was created by sleigh