Unexplained kidney failure in young people
Gene: WT1

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 18 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM and G2P. At least five variants reported
Created: 5 Aug 2016, 1:17 p.m.

Comment on phenotypes: Also associated with Denys-Drash syndrome 194080, Frasier syndrome 136680, Meacham syndrome 608978, Mesothelioma, somatic 156240; Wilms tumor, type 1 194070
Created: 5 Aug 2016, 1:16 p.m.

Comment on list classification: Promoted from Red to Green because this gene is Green in Version 1 of the Proteinuric renal disease gene panel
Created: 17 Jun 2016, 9:29 a.m.

Created: 17 Jun 2016, 9:29 a.m.

Panel version: 0.33

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Expert Review Green
Illumina TruGenome Clinical Sequencing Services
Radboud University Medical Center, Nijmegen
UKGTN
Emory Genetics Laboratory
Eligibility statement prior genetic testing

Phenotypes

Nephrotic syndrome, type 4 256370

OMIM

607102

Clinvar variants

Variants in WT1

Penetrance

Complete

Panels with this gene

History Filter Activity

30 Jan 2019, Gel status: 3

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Phenotypes for gene: WT1 were changed from Nephrotic syndrome, type 4 256370 to Nephrotic syndrome, type 4 256370

17 Aug 2016, Gel status: 4