Genodermatoses with malignancies

Gene: MSH6

Green List (high evidence)

MSH6 (mutS homolog 6)
EnsemblGeneIds (GRCh38): ENSG00000116062
EnsemblGeneIds (GRCh37): ENSG00000116062
OMIM: 600678, Gene2Phenotype
MSH6 is in 39 panels

1 review

Ellen Thomas (Genomics England Curator)

Comment on list classification: On prior testing list; less associated with Muir-Torre but familial bowel cancer could present in this category.
Created: 15 Feb 2016, 12:02 p.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
Phenotypes
  • Muir-Torre syndrome
OMIM
600678
Clinvar variants
Variants in MSH6
Penetrance
Complete
Panels with this gene

History Filter Activity

15 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

15 Feb 2016, Gel status: 4

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for MSH6 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

15 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

28 Aug 2015, Gel status: 0

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene MSH6 were set to Muir-Torre syndrome

27 Aug 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

MSH6 was added to Genodermatoses with malignanciespanel. Source: Eligibility statement prior genetic testing

17 Aug 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

MSH6 was added to Genodermatoses with malignanciespanel. Sources: Eligibility statement prior genetic testing