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  3. GLS
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Corneal abnormalities

Gene: GLS

Red List (low evidence)
GLS (glutaminase)
EnsemblGeneIds (GRCh38): ENSG00000115419
EnsemblGeneIds (GRCh37): ENSG00000115419
OMIM: 138280, Gene2Phenotype
GLS is in 8 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Red List (low evidence)

No evidence found for association with corneal abnormalities. Phenotypes from the mouse database: abnormal respiratory function, neonatal lethality complete penetrance, no abnormal phenotype detected and abnormal behavior. Seems to be a biomarker for some cancer types.
Created: 3 Mar 2017, 11:19 a.m.
This was known as GLS1.
Created: 3 Mar 2017, 11:12 a.m.
Added the 'watchlist' tag to look out for new publications.
Created: 22 Feb 2017, 10:54 a.m.
Created: 3 Mar 2017, 11:22 a.m.

Panel version: 0.205

Chris Campbell (NHS)

Red List (low evidence)

Kidney type glutaminase - biomarker for hepatocellular carcinoma
Created: 7 Feb 2017, 5:35 p.m.

Mode of inheritance
Unknown

Phenotypes
Corneal dystrophy abstract

Variants in this GENE are reported as part of current diagnostic practice

Created: 7 Feb 2017, 5:35 p.m.

Panel version: 0.3

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • GDL Corneal Abnormalities panel
Phenotypes
  • Corneal dystrophy abstract
Tags
watchlist
OMIM
138280
Clinvar variants
Variants in GLS
Penetrance
Complete
Publications
  • http://www.arvo.org/webs/am2015/abstract/304.pdf
Panels with this gene

History Filter Activity

9 Mar 2017, Gel status: 1

panel promoted to version 1

Chris Campbell (GEL)

09/03/2017 Revised and approved to Version 1.0 after expert and internal review.

9 Mar 2017, Gel status: 1

Gene classified by Genomics England curator

Chris Campbell (GEL)

This gene has been classified as Red List (Low Evidence).

3 Mar 2017, Gel status: 1

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for GLS were set to http://www.arvo.org/webs/am2015/abstract/304.pdf

3 Mar 2017, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

22 Feb 2017, Gel status: 2

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

22 Feb 2017, Gel status: 0

Changed Gene Name

Ellen McDonagh (Genomics England Curator)

GLS1* was changed to GLS

7 Feb 2017, Gel status: 0

Created

Chris Campbell (NHS)

GLS1* was created by Chricampbell

7 Feb 2017, Gel status: 0

Added New Source

Chris Campbell (NHS)

GLS1* was added to Corneal abnormalitiespanel. Sources: GDL Corneal Abnormalities panel