This Panel is marked as Internal
DNA Repair Genes pertinent cancer susceptibility
Gene: MRE11
MRE11 (MRE11 homolog, double strand break repair nuclease)
EnsemblGeneIds (GRCh38): ENSG00000020922
EnsemblGeneIds (GRCh37): ENSG00000020922
OMIM: 600814, Gene2Phenotype
MRE11 is in 17 panels
EnsemblGeneIds (GRCh38): ENSG00000020922
EnsemblGeneIds (GRCh37): ENSG00000020922
OMIM: 600814, Gene2Phenotype
MRE11 is in 17 panels
1 review
Louise Daugherty (Genomics England Curator)
MRE11 approved gene symbol in original gene list from http://sciencepark.mdanderson.org/labs/wood/dna_repair_genes.html.
Nomenclature history profile of this gene (from correspondence with HGNC) : a change was made in the 1990s of the gene symbol MRE11 to MRE11A which left a withdrawn MRE11 gene symbol even though this was really just a rename. Then, recently, MRE11A was named back to MRE11after MRE11B turned out to be a pseudogene and was renamed to MRE11P1. HGNC will now delete the MRE11~withdrawn symbol so that this confusion will not occur again. There is now only one MRE11 record, with HGNC:7230.Created: 4 Aug 2017, 8:32 a.m.
Details
- Sources
-
- Human DNA Repair Genes Database
- Phenotypes
-
- Class: Homologous recombination
- Activity: 3' exonuclease, defective in ATLD (ataxia-telangiectasia-like disorder)
- OMIM
- 600814
- Clinvar variants
- Variants in MRE11
- Penetrance
- Complete
- Panels with this gene
-
- Xeroderma pigmentosum, Trichothiodystrophy or Cockayne syndrome
- Severe microcephaly
- COVID-19 research
- Adult onset neurodegenerative disorder
- Ataxia and cerebellar anomalies - narrow panel
- Childhood onset dystonia, chorea or related movement disorder
- Hereditary ataxia with onset in adulthood
- Intellectual disability
- Ductal plate malformation
- Hereditary neuropathy or pain disorder
- Primary immunodeficiency or monogenic inflammatory bowel disease
- Hereditary ataxia
- Fetal anomalies
- DDG2P
- White matter disorders and cerebral calcification - narrow panel
- Hereditary neuropathy
- Hereditary haemorrhagic telangiectasia
History Filter Activity
7 Sep 2018, Gel status: 1
Panel promoted to version 1.0
Louise Daugherty (Genomics England Curator)Louise Daugherty: MRE11 approved gene symbol in
5 Nov 2017, Gel status: 1
Changed Gene Name
GEL ()MRE11A was changed to MRE11
5 Nov 2017, Gel status: 1
Removed Tag
GEL ()new-gene-name was removed from MRE11A. Panel: DNA Repair Genes
4 Aug 2017, Gel status: 0
Changed Gene Name
Louise Daugherty (Genomics England Curator)MRE11* was changed to MRE11A
21 Jun 2017, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)MRE11* was created by ellenmcdonagh
21 Jun 2017, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)MRE11* was added to DNA Repair Genespanel. Sources: Human DNA Repair Genes Database