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Idiopathic ventricular fibrillation

Gene: RYR2

Green List (high evidence)

RYR2 (ryanodine receptor 2)
EnsemblGeneIds (GRCh38): ENSG00000198626
EnsemblGeneIds (GRCh37): ENSG00000198626
OMIM: 180902, Gene2Phenotype
RYR2 is in 12 panels

2 reviews

Olivia Niblock (Genomics England Curator)

Comment on list classification: After clinical discussion and literature review of this variant, we have decided to class this gene as high evidence, due to different variations found in >3 unrelated individuals linked to Idiopathic Ventricular Fibrillation as described in the literature.
Created: 25 Jul 2017, 11:30 a.m.

Juan Pablo Kaski (Great Ormond Street Hospital/UCL)

Red List (low evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
CPVT

History Filter Activity

22 Mar 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

22rd March 2018. Panel reviews were assessed, and panel was revised according to reviews and further curation.

25 Jul 2017, Gel status: 4

Gene classified by Genomics England curator

Olivia Niblock (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

25 Jul 2017, Gel status: 4

Gene classified by Genomics England curator

Olivia Niblock (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

21 Jun 2017, Gel status: 0

Created

Juan Pablo Kaski (Great Ormond Street Hospital/UCL)

RYR2 was created by JKaski

21 Jun 2017, Gel status: 0

Added New Source

Juan Pablo Kaski (Great Ormond Street Hospital/UCL)

RYR2 was added to Idiopathic ventricular fibrillationpanel. Sources: Expert Review