Molecular autopsy
Gene: ANK2
This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.Created: 20 Feb 2019, 2:17 p.m.
Gene currently tested on Manchester cardiac gene panel. Only class 1-3 variants detected to date. 75 variants listed on HGMD (accessed 29/01/2019). ClinGen Knowledge Base: disputed association with Brugada syndrome 1 (accessed 29/01/2019).Created: 14 Feb 2019, 1:38 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Cardiac arrhythmia, ankyrin-B-related (600919); Long QT syndrome 4 (600919)
Publications
Variants in this GENE are reported as part of current diagnostic practice
Source London South GLH was added to ANK2.
Source North West GLH was added to ANK2. Added phenotypes Cardiac arrhythmia, ankyrin-B-related (600919); Long QT syndrome 4 (600919) for gene: ANK2 Publications for gene ANK2 were changed from to 12571597; 27761167; 27818464; 19862833; 16301704; 30420954
gene: ANK2 was added gene: ANK2 was added to Molecular autopsy. Sources: Expert Review Green Mode of inheritance for gene: ANK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: ANK2 were set to Long QT syndrome-4; Cardiac arrhythmia, ankyrin-B-related 600919; Brugada/Brugada like syndrome; catecholaminergic polymorphic ventricular tachycardia; Long QT syndrome 4 600919