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  3. ANGPT2
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DDG2P

Gene: ANGPT2

Red List (low evidence)
ANGPT2 (angiopoietin 2)
EnsemblGeneIds (GRCh38): ENSG00000091879
EnsemblGeneIds (GRCh37): ENSG00000091879
OMIM: 601922, Gene2Phenotype
ANGPT2 is in 4 panels

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Red List (low evidence)

The DDG2P confidence category, allelic requirement and molecular mechanism for ANGPT2-related non-immune hydrops fetalis are limited, biallelic_autosomal and loss of function (PMID:34876502). More details can be found in https://www.ebi.ac.uk/gene2phenotype/lgd/G2P03493.
Created: 13 Feb 2026, 9:25 p.m. | Last Modified: 13 Feb 2026, 9:25 p.m.
Panel Version: 6.17
The DDG2P confidence category for the disease ANGPT2-related non-immune hydrops fetalis is limited. The allelic requirement and mutation consequence are biallelic_autosomal and decreased gene product level (PMID: 34876502).
Created: 26 Sep 2024, 8:30 p.m. | Last Modified: 26 Sep 2024, 8:30 p.m.
Panel Version: 4.10

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
ANGPT2-related non-immune hydrops fetalis

Publications

Mode of pathogenicity
Other

Created: 26 Sep 2024, 8:30 p.m.
Last Modified: 26 Sep 2024, 8:30 p.m.
Panel version: 6.17

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • DD-Gene2Phenotype
  • Expert Review Red
Phenotypes
  • ANGPT2-related non-immune hydrops fetalis
OMIM
601922
Clinvar variants
Variants in ANGPT2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 Feb 2026, Gel status: 1

Set mode of pathogenicity

Achchuthan Shanmugasundram (Genomics England Curator)

Mode of pathogenicity for gene: ANGPT2 was changed from Other to None

26 Sep 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set mode of pathogenicity

Achchuthan Shanmugasundram (Genomics England Curator)

gene: ANGPT2 was added gene: ANGPT2 was added to DDG2P. Sources: Expert Review Red,DD-Gene2Phenotype Mode of inheritance for gene: ANGPT2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ANGPT2 were set to 34876502 Phenotypes for gene: ANGPT2 were set to ANGPT2-related non-immune hydrops fetalis Mode of pathogenicity for gene: ANGPT2 was set to Other