DDG2P
Gene: UNC79

UNC79 (unc-79 homolog, NALCN channel complex subunit)
EnsemblGeneIds (GRCh38): ENSG00000133958
EnsemblGeneIds (GRCh37): ENSG00000133958
OMIM: 616884, Gene2Phenotype
UNC79 is in 1 panel

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Red List (low evidence)

The DDG2P confidence category, allelic requirement and molecular mechanism for UNC79-related intellectual disability with focal motor seizures are limited, monoallelic_autosomal and loss of function (PMID:37183800). More details can be found in https://www.ebi.ac.uk/gene2phenotype/lgd/G2P03702.
Created: 13 Feb 2026, 9:26 p.m. | Last Modified: 13 Feb 2026, 9:26 p.m.

Panel Version: 6.17

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
UNC79-related intellectual disability with focal motor seizures

Publications

37183800

Created: 13 Feb 2026, 9:26 p.m.
Last Modified: 13 Feb 2026, 9:26 p.m.
Panel version: 6.17

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

DD-Gene2Phenotype
Expert Review Red

Phenotypes

UNC79-related intellectual disability with focal motor seizures

OMIM

616884

Clinvar variants

Variants in UNC79

Penetrance

None

Publications

37183800

Panels with this gene

DDG2P

History Filter Activity

13 Feb 2026, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

gene: UNC79 was added gene: UNC79 was added to DDG2P. Sources: Expert Review Red,DD-Gene2Phenotype Mode of inheritance for gene: UNC79 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: UNC79 were set to 37183800 Phenotypes for gene: UNC79 were set to UNC79-related intellectual disability with focal motor seizures

DDG2P Gene: UNC79