Possible mitochondrial disorder - nuclear genes
Gene: WARS2Comment on list classification: Confirmed on the NHSE GMS Mitochondrial Specialist Group Meeting call on 25th February 2019 that this gene should be Green.Created: 25 Feb 2019, 5:34 p.m.
Initial gene list and info collated by Carl Fratter (Oxford University Hospitals NHS Trust) January 2019 on behalf of the GMS Mitochondrial specialist test group.Created: 4 Feb 2019, 1:36 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures, 617710
Multiple unrelated individuals with bi-alllelic variants in this gene reported in the literature now.Created: 1 Sep 2018, 5:29 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures, MIM#617710
Publications
Variants in this GENE are reported as part of current diagnostic practice
no mutation reports in literature; good candidate geneCreated: 6 Feb 2016, 11:38 p.m.
Gene: wars2 has been classified as Green List (High Evidence).
Publications for gene: WARS2 were set to
Gene: wars2 has been classified as Green List (High Evidence).
gene: WARS2 was added gene: WARS2 was added to Possible mitochondrial disorder - nuclear genes. Sources: NHS GMS,Expert Review Green Mode of inheritance for gene: WARS2 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: WARS2 were set to Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures, 617710