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Haematological malignancies cancer susceptibility

Gene: PARN

Green List (high evidence)
PARN (poly(A)-specific ribonuclease)
EnsemblGeneIds (GRCh38): ENSG00000140694
EnsemblGeneIds (GRCh37): ENSG00000140694
OMIM: 604212, Gene2Phenotype
PARN is in 12 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Comment on mode of inheritance: This gene was reviewed by Lara Hawkes (Cancer Clinical Team, Genomics England) and agrees the mode of inheritance is 'both'.
Created: 20 Aug 2018, 1:17 p.m.
Created: 20 Aug 2018, 1:17 p.m.

Panel version: 0.31

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Created: 26 Jul 2017, 11:15 a.m.

Panel version: 0.8

Details

Mode of Inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Curated sources
Phenotypes
  • Dyskeratosis congenita, autosomal recessive 6, OMIM:616353
  • Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4, OMIM:616371
OMIM
604212
Clinvar variants
Variants in PARN
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

13 Apr 2022, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: PARN were changed from Class: BM failure syndrome (typ AR); Dyskeratosis congenita; MDS, AML; Oral and GI squamous cell carcinoma to Dyskeratosis congenita, autosomal recessive 6, OMIM:616353; Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4, OMIM:616371

7 Sep 2018, Gel status: 4

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Comment on mode of inheritance

20 Aug 2018, Gel status: 4

Set mode of inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for gene: PARN was changed from BOTH monoallelic and biallelic, autosomal or pseudoautosomal to BOTH monoallelic and biallelic, autosomal or pseudoautosomal

30 Jan 2018, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

Expert Review Green was added to PARN. Panel: Haematological malignancies pertinent cancer susceptibility

21 Jun 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

PARN was created by ellenmcdonagh

21 Jun 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

PARN was added to Haematological malignanciespanel. Sources: Curated sources