Haematological malignancies cancer susceptibility

Gene: WAS

Green List (high evidence)

WAS (Wiskott-Aldrich syndrome)
EnsemblGeneIds (GRCh38): ENSG00000015285
EnsemblGeneIds (GRCh37): ENSG00000015285
OMIM: 300392, Gene2Phenotype
WAS is in 12 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Added the tag ‘gene-therapy-trial’ as this gene is within the Gene Therapy Panel available here: https://panelapp.genomicsengland.co.uk/panels/412
Created: 14 May 2018, 10:02 a.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Details

Mode of Inheritance
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Sources
  • Expert Review Green
  • Curated sources
Phenotypes
  • Class: BM failure syndrome (typ AR)
  • X-linked neutropenia
  • Wiskott Adrich Syndrome
  • lymphoma
  • MDS, AML, Lymphoma
Tags
gene-therapy-trial
OMIM
300392
Clinvar variants
Variants in WAS
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

7 Sep 2018, Gel status: 4

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Added the tag ‘gene-therapy-tr

30 Jan 2018, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

Expert Review Green was added to WAS. Panel: Haematological malignancies pertinent cancer susceptibility

21 Jun 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

WAS was added to Haematological malignanciespanel. Sources: Curated sources

21 Jun 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

WAS was created by ellenmcdonagh