Haematological malignancies cancer susceptibility
Gene: STX11EnsemblGeneIds (GRCh38): ENSG00000135604
EnsemblGeneIds (GRCh37): ENSG00000135604
OMIM: 605014, Gene2Phenotype
STX11 is in 6 panels
1 review
Ellen McDonagh (Genomics England Curator)
Comment on list classification: Promoted to Amber for review.Created: 3 Apr 2019, 3:44 p.m.
This gene was present on a list submitted by Clare Turnbull. PMID: 16582076: Two of the six patients harbouring STX11 gene defects developed myelodysplastic syndrome (MDS) or acute myelogenous leukaemia (AML).
Sources: Expert list, LiteratureCreated: 3 Apr 2019, 3:40 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Hemophagocytic lymphohistiocytosis, familial, 4 603552
Publications
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Amber
- Literature
- Expert list
- Phenotypes
-
- Hemophagocytic lymphohistiocytosis, familial, 4 603552
- OMIM
- 605014
- Clinvar variants
- Variants in STX11
- Penetrance
- None
- Publications
- Panels with this gene
History Filter Activity
Entity classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)Gene: stx11 has been classified as Amber List (Moderate Evidence).
Set publications
Ellen McDonagh (Genomics England Curator)Publications for gene STX11 were changed from 16582076 to 16582076; 26176172
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes
Ellen McDonagh (Genomics England Curator)gene: STX11 was added gene: STX11 was added to Haematological malignancies cancer susceptibility. Sources: Expert list,Literature Mode of inheritance for gene: STX11 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: STX11 were set to 16582076 Phenotypes for gene: STX11 were set to Hemophagocytic lymphohistiocytosis, familial, 4 603552