This Panel is marked as Internal
Groopman et al 2019 - Genes with diagnostic variants
Gene: KRAS
KRAS (KRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 30 panels
EnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 30 panels
1 review
Eleanor Williams (Genomics England Curator)
From Groopman et al 2019 Table S7. Gene symbol: KRAS; Inheritance: AD; Clinical diagnosis: Glomerulopathy; Genetic diagnosis: Noonan syndrome 3; OMIM phenotype MIM No.: 609942; Number of cases: 1Created: 2 Jul 2019, 9:46 p.m. | Last Modified: 2 Jul 2019, 9:46 p.m.
Panel Version: 0.4
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- Expert Review Red
- Expert review red
- Literature
- Phenotypes
-
- MIM 609942
- Glomerulopathy
- Noonan syndrome 3
- OMIM
- 190070
- Clinvar variants
- Variants in KRAS
- Penetrance
- None
- Panels with this gene
-
- Fetal anomalies
- DDG2P
- Mosaic skin disorders - deep sequencing
- Hereditary neuropathy or pain disorder
- Fetal hydrops
- Early onset or syndromic epilepsy
- Rare syndromic craniosynostosis or isolated multisuture synostosis
- Familial rhabdomyosarcoma
- Paediatric or syndromic cardiomyopathy
- RASopathies
- IUGR and IGF abnormalities
- Hereditary neuropathy
- Childhood solid tumours cancer susceptibility
- Primary lymphoedema
- Multiple monogenic benign skin tumours
- Sarcoma cancer susceptibility
- Cytopenias and congenital anaemias
- COVID-19 research
- Neurological segmental overgrowth
- Segmental overgrowth disorders - Deep sequencing
- Embryonal tumour of possible germline origin
- Sarcoma susceptibility
- Osteogenesis imperfecta
- Monogenic short stature
- Adult solid tumours cancer susceptibility
- Pigmentary skin disorders
- Childhood solid tumours
- Sarcoma of possible germline origin
- Intellectual disability
- Primary immunodeficiency or monogenic inflammatory bowel disease
History Filter Activity
2 Jul 2019, Gel status: 1
Added New Source
Eleanor Williams (Genomics England Curator)Source Expert Review Red was added to KRAS.
2 Jul 2019, Gel status: 1
Created, Added New Source, Set mode of inheritance, Set Phenotypes
Eleanor Williams (Genomics England Curator)gene: KRAS was added gene: KRAS was added to Groopman et al 2019 - Genes with diagnostic variants. Sources: Literature,Expert review red Mode of inheritance for gene: KRAS was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: KRAS were set to MIM 609942; Glomerulopathy; Noonan syndrome 3