Sudden cardiac death - previous panel
Gene: ANK2EnsemblGeneIds (GRCh38): ENSG00000145362
EnsemblGeneIds (GRCh37): ENSG00000145362
OMIM: 106410, Gene2Phenotype
ANK2 is in 12 panels
2 reviews
Ellen McDonagh (Genomics England Curator)
This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.Created: 20 Feb 2019, 2:17 p.m.
James Eden (Manchester)
Gene currently tested on Manchester cardiac gene panel. Only class 1-3 variants detected to date. 75 variants listed on HGMD (accessed 29/01/2019). ClinGen Knowledge Base: disputed association with Brugada syndrome 1 (accessed 29/01/2019).Created: 14 Feb 2019, 1:38 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Cardiac arrhythmia, ankyrin-B-related (600919); Long QT syndrome 4 (600919)
Publications
Variants in this GENE are reported as part of current diagnostic practice
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- London South GLH
- North West GLH
- Expert Review Green
- London South GLH
- North West GLH
- Expert Review Green
- Phenotypes
-
- Cardiac arrhythmia, ankyrin-B-related (600919)
- Long QT syndrome-4
- Long QT syndrome 4 (600919)
- Cardiac arrhythmia, ankyrin-B-related 600919
- catecholaminergic polymorphic ventricular tachycardia
- Brugada/Brugada like syndrome
- Long QT syndrome 4 600919
- OMIM
- 106410
- Clinvar variants
- Variants in ANK2
- Penetrance
- None
- Publications
- Panels with this gene
-
- Paediatric or syndromic cardiomyopathy
- Short QT syndrome
- Progressive cardiac conduction disease
- Catecholaminergic polymorphic VT
- Cardiac arrhythmias - additional genes
- Brugada syndrome and cardiac sodium channel disease
- Long QT syndrome
- Intellectual disability
- DDG2P
- Early onset or syndromic epilepsy
- Arrhythmogenic right ventricular cardiomyopathy
- Dilated and arrhythmogenic cardiomyopathy
History Filter Activity
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes
Ivone Leong (Genomics England Curator)gene: ANK2 was added gene: ANK2 was added to Sudden cardiac death. Sources: Expert Review Green,North West GLH,London South GLH Mode of inheritance for gene: ANK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: ANK2 were set to 27761167; 16301704; 27818464; 19862833; 30420954; 12571597 Phenotypes for gene: ANK2 were set to Cardiac arrhythmia, ankyrin-B-related (600919); Long QT syndrome-4; Long QT syndrome 4 (600919); Cardiac arrhythmia, ankyrin-B-related 600919; catecholaminergic polymorphic ventricular tachycardia; Brugada/Brugada like syndrome; Long QT syndrome 4 600919