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  3. ALG10
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Long QT syndrome

Gene: ALG10

Red List (low evidence)
ALG10 (ALG10, alpha-1,2-glucosyltransferase)
EnsemblGeneIds (GRCh38): ENSG00000139133
EnsemblGeneIds (GRCh37): ENSG00000139133
OMIM: 603313, Gene2Phenotype
ALG10 is in 3 panels

5 reviews

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

ALG10 OMIM:618355 is not associated with Short QT phenotype in OMIM or in Gen2Phen. However, ALG10B OMIM:603313 is associated with Long QT syndrome, acquired, reduced susceptibility to OMIM:613688 (PMID:15280551). ALG10 was added to this panel in error.
Created: 28 Oct 2021, 2:13 p.m. | Last Modified: 28 Oct 2021, 2:13 p.m.
Panel Version: 2.26
Created: 28 Oct 2021, 2:13 p.m.
Last Modified: 28 Oct 2021, 2:13 p.m.
Panel version: 2.26

Rebecca Whittington (South West GLH)

Red List (low evidence)

{Long QT syndrome, acquired, reduced susceptibility to} (OMIM 613688)
Created: 25 Mar 2019, 4:30 p.m.
No evidence for this gene to include. PMID:15280551
Created: 25 Mar 2019, 4:27 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Created: 25 Mar 2019, 4:24 p.m.

Panel version: 1.26

Ellen McDonagh (Genomics England Curator)

Not on the Inherited Cardiac Condition Genes panel reported in: Development of a Comprehensive Sequencing Assay for Inherited Cardiac Condition Genes, Pua et al, Journal of Cardiovascular Translational Research, online Feb 2016 (doi:10.​1007/​s12265-016-9673-5). The panel contains disease-causing, putatively pathogenic, research and phenocopy genes.
Created: 19 Feb 2016, 11:07 a.m.
Created: 19 Feb 2016, 11:07 a.m.

Panel version: 0.18

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

I don't know

Created: 6 Jan 2016, 5:29 p.m.

Panel version: 0.0

Bill Newman (Manchester Centre for Genomic Medicine)

Red List (low evidence)

this is a modifier gene not a LQT disease associated gene
Created: 2 Dec 2015, 5 p.m.

Publications

Created: 2 Dec 2015, 5 p.m.

Panel version: 0

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • South West GLH
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Progressive myoclonus epilepsy
  • CDG
OMIM
603313
Clinvar variants
Variants in ALG10
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

28 Oct 2021, Gel status: 1

Set mode of inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for gene: ALG10 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BIALLELIC, autosomal or pseudoautosomal

28 Oct 2021, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: ALG10 were set to 15280551

28 Oct 2021, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: ALG10 were changed from {Acquired long QT syndrome, reduced susceptibility to}, 613688 to Progressive myoclonus epilepsy; CDG

28 Oct 2021, Gel status: 1

Removed Tag

Sarah Leigh (Genomics England Curator)

Tag new-gene-name was removed from gene: ALG10.

28 Oct 2021, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: ALG10 were set to

26 Oct 2021, Gel status: 1

Added Tag

Sarah Leigh (Genomics England Curator)

Tag new-gene-name tag was added to gene: ALG10.

21 Feb 2019, Gel status: 1

Added New Source, Set mode of inheritance

Ellen McDonagh (Genomics England Curator)

Source South West GLH was added to ALG10. Mode of inheritance for gene ALG10 was changed from to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

13 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

ALG10 was added to Long QT syndromepanel. Sources: Radboud University Medical Center, Nijmegen