Long QT syndrome

Gene: ALG10

Red List (low evidence)

ALG10 (ALG10, alpha-1,2-glucosyltransferase)
EnsemblGeneIds (GRCh38): ENSG00000139133
EnsemblGeneIds (GRCh37): ENSG00000139133
OMIM: 603313, Gene2Phenotype
ALG10 is in 2 panels

4 reviews

Rebecca Whittington (South West GLH)

Red List (low evidence)

{Long QT syndrome, acquired, reduced susceptibility to} (OMIM 613688)
Created: 25 Mar 2019, 4:30 p.m.
No evidence for this gene to include. PMID:15280551
Created: 25 Mar 2019, 4:27 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Ellen McDonagh (Genomics England Curator)

Not on the Inherited Cardiac Condition Genes panel reported in: Development of a Comprehensive Sequencing Assay for Inherited Cardiac Condition Genes, Pua et al, Journal of Cardiovascular Translational Research, online Feb 2016 (doi:10.​1007/​s12265-016-9673-5). The panel contains disease-causing, putatively pathogenic, research and phenocopy genes.
Created: 19 Feb 2016, 11:07 a.m.

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

I don't know

Bill Newman (Manchester Centre for Genomic Medicine)

Red List (low evidence)

this is a modifier gene not a LQT disease associated gene
Created: 2 Dec 2015, 5 p.m.

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • South West GLH
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • {Acquired long QT syndrome, reduced susceptibility to}, 613688
OMIM
603313
Clinvar variants
Variants in ALG10
Penetrance
Complete
Panels with this gene

History Filter Activity

21 Feb 2019, Gel status: 1

Added New Source, Set mode of inheritance

Ellen McDonagh (Genomics England Curator)

Source South West GLH was added to ALG10. Mode of inheritance for gene ALG10 was changed from to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

13 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

ALG10 was added to Long QT syndromepanel. Sources: Radboud University Medical Center, Nijmegen