This Panel is marked as Internal
Young adult onset cancer
Gene: TP53
TP53 (tumor protein p53)
EnsemblGeneIds (GRCh38): ENSG00000141510
EnsemblGeneIds (GRCh37): ENSG00000141510
OMIM: 191170, Gene2Phenotype
TP53 is in 26 panels
EnsemblGeneIds (GRCh38): ENSG00000141510
EnsemblGeneIds (GRCh37): ENSG00000141510
OMIM: 191170, Gene2Phenotype
TP53 is in 26 panels
1 review
Ellen McDonagh (Genomics England Curator)
Mode of inheritance
Unknown
Phenotypes
HER2+ breast cancer; Lung cancer
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Eligibility statement prior genetic testing
- Phenotypes
-
- HER2+ breast cancer
- OMIM
- 191170
- Clinvar variants
- Variants in TP53
- Penetrance
- Complete
- Panels with this gene
-
- Inherited ovarian cancer (without breast cancer)
- Cytopenia - NOT Fanconi anaemia
- Childhood solid tumours cancer susceptibility
- Inherited phaeochromocytoma and paraganglioma
- Familial breast cancer
- Adult solid tumours cancer susceptibility
- Haematological malignancies cancer susceptibility
- Brain cancer pertinent cancer susceptibility
- Familial Tumours Syndromes of the central & peripheral Nervous system
- Skeletal dysplasia
- Sarcoma cancer susceptibility
- Embryonal tumour of possible germline origin
- Cytopenias and congenital anaemias
- COVID-19 research
- Familial rhabdomyosarcoma
- Breast cancer pertinent cancer susceptibility
- Haematological malignancies for rare disease
- Adult solid tumours for rare disease
- Sarcoma of possible germline origin
- GI tract tumours
- Sarcoma susceptibility
- Endocrine neoplasia
- Inherited predisposition to acute myeloid leukaemia (AML)
- Multiple endocrine tumours
- Li Fraumeni Syndrome
- Childhood solid tumours
History Filter Activity
16 Mar 2017, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)TP53 was created by ellenmcdonagh
16 Mar 2017, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)TP53 was added to Young adult onset cancerpanel. Sources: Eligibility statement prior genetic testing