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Inherited predisposition to acute myeloid leukaemia (AML) v1.11 RUNX1 Arina Puzriakova Phenotypes for gene: RUNX1 were changed from 601399 (OMIM phenotype description ID); 601626 Leukemia, acute myeloid; 601399 Platelet disorder, familial, with associated myeloid malignancy to Leukemia, acute myeloid, OMIM:601626; Platelet disorder, familial, with associated myeloid malignancy, OMIM:601399
Inherited predisposition to acute myeloid leukaemia (AML) v0.40 RUNX1 Louise Daugherty Classified gene: RUNX1 as Green List (high evidence)
Inherited predisposition to acute myeloid leukaemia (AML) v0.40 RUNX1 Louise Daugherty Added comment: Comment on list classification: As discussed in the GMS Haematology Specialist Test Group webex call 8th March 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene Green.
Inherited predisposition to acute myeloid leukaemia (AML) v0.40 RUNX1 Louise Daugherty Gene: runx1 has been classified as Green List (High Evidence).
Inherited predisposition to acute myeloid leukaemia (AML) v0.39 RUNX1 Louise Daugherty Publications for gene: RUNX1 were set to 19357396; 23926458; 11830488
Inherited predisposition to acute myeloid leukaemia (AML) v0.16 RUNX1 Paula Page reviewed gene: RUNX1: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 30466750, PMID: 27895058, PMID: 27069254; Phenotypes: 601399 Platelet disorder, familial, with associated myeloid malignancy, 601626 Leukemia, acute myeloid; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Inherited predisposition to acute myeloid leukaemia (AML) v0.16 RUNX1 Louise Daugherty commented on gene: RUNX1: Initial gene list (Consensus Genes for SPEC HAEM Panels 31.01.19 North West v1 FINAL.xlsx) collated by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group. Gene Symbol submitted: RUNX1; Suggested initial gene rating: Green List (high evidence); Are variants in this gene part of your current diagnostic practice? Yes; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Phenotypes: 601626 Leukemia, acute myeloid; 601399 Platelet disorder, familial, with associated myeloid malignancy; PMID(s): none submitted
Inherited predisposition to acute myeloid leukaemia (AML) v0.15 RUNX1 Steve Keeney reviewed gene: RUNX1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: 601626 Leukemia, acute myeloid, 601399 Platelet disorder, familial, with associated myeloid malignancy; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Inherited predisposition to acute myeloid leukaemia (AML) v0.14 RUNX1 Louise Daugherty Added phenotypes 601626 Leukemia, acute myeloid; 601399 Platelet disorder, familial, with associated myeloid malignancy for gene: RUNX1
Inherited predisposition to acute myeloid leukaemia (AML) v0.12 RUNX1 Louise Daugherty Source North West GLH was added to RUNX1.
Inherited predisposition to acute myeloid leukaemia (AML) v0.11 RUNX1 Louise Daugherty commented on gene: RUNX1: Initial gene list (Consensus Genes for Panels_Haem_SHEFFIELD-29.01.2019.xlsx) collated by Mandy Nesbitt Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Trust January 2019 on behalf of Yorkshire and North East GLH for the GMS Haematology specialist test group. Gene Symbol submitted: RUNX1; Suggested intial gene rating: Green List (high evidence); Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Phenotypes: 601626 Leukemia, acute myeloid; 601399 Platelet disorder, familial, with associated myeloid malignancy; PMID(s): none submitted
Inherited predisposition to acute myeloid leukaemia (AML) v0.10 RUNX1 Mandy nesbitt reviewed gene: RUNX1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: 601626 Leukemia, acute myeloid, 601399 Platelet disorder, familial, with associated myeloid malignancy; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Inherited predisposition to acute myeloid leukaemia (AML) v0.9 RUNX1 Louise Daugherty Added phenotypes 601626 Leukemia, acute myeloid; 601399 Platelet disorder, familial, with associated myeloid malignancy for gene: RUNX1
Inherited predisposition to acute myeloid leukaemia (AML) v0.7 RUNX1 Louise Daugherty Source Yorkshire and North East GLH was added to RUNX1.
Inherited predisposition to acute myeloid leukaemia (AML) v0.6 RUNX1 Louise Daugherty reviewed gene: RUNX1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Inherited predisposition to acute myeloid leukaemia (AML) v0.5 RUNX1 Carl Fratter reviewed gene: RUNX1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Inherited predisposition to acute myeloid leukaemia (AML) v0.4 RUNX1 Louise Daugherty Source NHS GMS was added to RUNX1.
Added phenotypes 601399 (OMIM phenotype description ID) for gene: RUNX1
Inherited predisposition to acute myeloid leukaemia (AML) v0.3 RUNX1 Louise Daugherty Source Expert Review Amber was added to RUNX1.
Mode of inheritance for gene RUNX1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Added phenotypes 601399 (OMIM phenotype description ID) for gene: RUNX1
Publications for gene RUNX1 were changed from to 19357396; 23926458; 11830488
Rating Changed from Red List (low evidence) to Amber List (moderate evidence)
Inherited predisposition to acute myeloid leukaemia (AML) v0.2 RUNX1 Louise Daugherty gene: RUNX1 was added
gene: RUNX1 was added to Inherited predisposition to acute myeloid leukaemia (AML). Sources: Wessex and West Midlands GLH
Mode of inheritance for gene: RUNX1 was set to