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Inherited predisposition to acute myeloid leukaemia (AML) v1.12 | TERC | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with Pulmonary fibrosis, idiopathic, susceptibility to (MIM#614743) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v1.12 | TERC | Arina Puzriakova Phenotypes for gene: TERC were changed from Dyskeratosis congenita, autosomal dominant 1, 27550; Aplastic anemia, 614743; Pulmonary fibrosis, idiopathic, susceptibility to, 614743 to Dyskeratosis congenita, autosomal dominant 1, OMIM:127550; {Aplastic anemia}, OMIM:614743 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.29 | TERC | Louise Daugherty Phenotypes for gene: TERC were changed from 127550 (OMIM phenotype description ID); 614743 {Aplastic anemia}; 127550 / 614743 {Aplastic anemia} to Dyskeratosis congenita, autosomal dominant 1, 27550; Aplastic anemia, 614743; Pulmonary fibrosis, idiopathic, susceptibility to, 614743 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.28 | TERC | Louise Daugherty Publications for gene: TERC were set to 23926458; 28600339 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.23 | TERC | Louise Daugherty Classified gene: TERC as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.23 | TERC | Louise Daugherty Added comment: Comment on list classification: As discussed in the GMS Haematology Specialist Test Group webex call 8th March 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene Green. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.23 | TERC | Louise Daugherty Gene: terc has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.16 | TERC | Paula Page reviewed gene: TERC: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 30466750, PMID: 27895058, PMID: 27069254; Phenotypes: 127550 Dyskeratosis congenita, autosomal dominant 1, Aplastic anemia 614743, Pulmonary fibrosis, idiopathic, susceptibility to 614743; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.16 | TERC | Louise Daugherty commented on gene: TERC: Initial gene list (Consensus Genes for SPEC HAEM Panels 31.01.19 North West v1 FINAL.xlsx) collated by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group. Gene Symbol submitted: TERC; Suggested initial gene rating: Green List (high evidence); Are variants in this gene part of your current diagnostic practice? Yes; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Phenotypes: 127550 / 614743 {Aplastic anemia}; PMID(s): none submitted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.15 | TERC | Steve Keeney reviewed gene: TERC: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: 127550 / 614743 {Aplastic anemia}; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.14 | TERC | Louise Daugherty Added phenotypes 127550 / 614743 {Aplastic anemia} for gene: TERC | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.12 | TERC | Louise Daugherty Source North West GLH was added to TERC. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.11 | TERC | Louise Daugherty commented on gene: TERC: Initial gene list (Consensus Genes for Panels_Haem_SHEFFIELD-29.01.2019.xlsx) collated by Mandy Nesbitt Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Trust January 2019 on behalf of Yorkshire and North East GLH for the GMS Haematology specialist test group. Gene Symbol submitted: TERC; Suggested intial gene rating: Green List (high evidence); Are variants in this gene part of your current diagnostic practice? Yes; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Phenotypes: 614743 {Aplastic anemia}; PMID(s): none submitted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.10 | TERC | Mandy nesbitt reviewed gene: TERC: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: 614743 {Aplastic anemia}; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.9 | TERC | Louise Daugherty Added phenotypes 614743 {Aplastic anemia} for gene: TERC | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.7 | TERC | Louise Daugherty Source Yorkshire and North East GLH was added to TERC. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.6 | TERC | Louise Daugherty reviewed gene: TERC: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.5 | TERC | Carl Fratter reviewed gene: TERC: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inherited predisposition to acute myeloid leukaemia (AML) v0.4 | TERC |
Louise Daugherty Source NHS GMS was added to TERC. Added phenotypes 127550 (OMIM phenotype description ID) for gene: TERC |
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Inherited predisposition to acute myeloid leukaemia (AML) v0.3 | TERC |
Louise Daugherty Source Expert Review Amber was added to TERC. Mode of inheritance for gene TERC was changed from to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Added phenotypes 127550 (OMIM phenotype description ID) for gene: TERC Publications for gene TERC were changed from to 23926458; 28600339 Rating Changed from Red List (low evidence) to Amber List (moderate evidence) |
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Inherited predisposition to acute myeloid leukaemia (AML) v0.2 | TERC |
Louise Daugherty gene: TERC was added gene: TERC was added to Inherited predisposition to acute myeloid leukaemia (AML). Sources: Wessex and West Midlands GLH Mode of inheritance for gene: TERC was set to |