| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Viral resistance v0.36 | CCL2 |
Ivone Leong changed review comment from: Comment on list classification: PMID: 14571188 found that three SNPs (-2136T CCL2 promoter region, 767G intron 1 of CCL2 and -1385A of Eotaxin promoter) were nearly always found together on a 31kb haplotype (H7), which contains all three regoins. The frequencies for these three variants and H7 haplotype were significantly increased in uninfected European-Americans who were repeatedly exposed to HIV-1. The study suggests that this region influences HIV susceptibility/resistance. There is currently not enough evidence so this gene will remain Red.; to: Comment on list classification: PMID: 14571188 found that three SNPs (-2136T CCL2 promoter region, 767G intron 1 of CCL2 and -1385A of Eotaxin promoter) were nearly always found together on a 31kb haplotype (H7), which contains all three regoins. The frequencies for these three variants and H7 haplotype were significantly increased in uninfected European-Americans who were repeatedly exposed to HIV-1. The study suggests that this region influences HIV susceptibility/resistance. |
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| Viral resistance v0.36 | CCL2 | Ivone Leong Classified gene: CCL2 as Red List (low evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.36 | CCL2 |
Ivone Leong Added comment: Comment on list classification: PMID: 14571188 found that three SNPs (-2136T CCL2 promoter region, 767G intron 1 of CCL2 and -1385A of Eotaxin promoter) were nearly always found together on a 31kb haplotype (H7), which contains all three regoins. The frequencies for these three variants and H7 haplotype were significantly increased in uninfected European-Americans who were repeatedly exposed to HIV-1. The study suggests that this region influences HIV susceptibility/resistance. There is currently not enough evidence so this gene will remain Red. |
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| Viral resistance v0.36 | CCL2 | Ivone Leong Gene: ccl2 has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.20 | CCL2 |
Sarah Leigh gene: CCL2 was added gene: CCL2 was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: CCL2 was set to Publications for gene: CCL2 were set to 14571188 Phenotypes for gene: CCL2 were set to {HIV-1, resistance to} 609423 |
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