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Viral resistance v0.63 DDX58 Eleanor Williams commented on gene: DDX58
Viral resistance v0.63 DDX58 Eleanor Williams Tag new-gene-name tag was added to gene: DDX58.
Viral resistance v0.53 DDX58 Ivone Leong Classified gene: DDX58 as Amber List (moderate evidence)
Viral resistance v0.53 DDX58 Ivone Leong Gene: ddx58 has been classified as Amber List (Moderate Evidence).
Viral resistance v0.41 DDX58 Sarah Leigh gene: DDX58 was added
gene: DDX58 was added to Viral resistance. Sources: Literature
Mode of inheritance for gene: DDX58 was set to Unknown
Publications for gene: DDX58 were set to 21939710; 16625202; 15737993; 25749629
Review for gene: DDX58 was set to AMBER
Added comment: PMID 21939710 found DDX5 (formerly known as RIGI) was essential for virus-induced expression of IRF3 and concluded that DDX5 is essential for detection and eradication of replicating viral genomes. PMID 16625202 reported that DDX58 is essential for the production of interferons in response to certain RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
Numerous reports of wild type DDX5 activity in anti-viral responses.
Sources: Literature