| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Viral resistance v0.38 | LDLR | Ivone Leong Classified gene: LDLR as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.38 | LDLR | Ivone Leong Added comment: Comment on list classification: Promoted to Green based on review from Sarah Leigh (Genomics England Curator). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.38 | LDLR | Ivone Leong Gene: ldlr has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.35 | LDLR |
Sarah Leigh gene: LDLR was added gene: LDLR was added to Viral resistance. Sources: Literature Mode of inheritance for gene: LDLR was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: LDLR were set to 10535997; 32268133; 31386864; 31358055 Phenotypes for gene: LDLR were set to Hypercholesterolemia, familial, 1 143890; LDL cholesterol level QTL2 143890 Review for gene: LDLR was set to GREEN Added comment: Hepatitis C virus (HCV) and other viruses can enter cells via LDLR mediated endocytosis (PMID 32268133). PMID 10535997 demonstrates that lack of detectable LDL receptor on cells results in resistance to infection by bovine viral diarrheal virus. Dengue virus genome replication and protein synthesis was significantly inhibited by the serine protease inhibitor AEBSF [4-(2-aminoethyl) benzene sulfonyl fluoride] that inhibits the expression of genes HMGCS, HMGCR & LDLR (PMID 31386864). A recent LDLR-null FH cell model has been developed, which is permisive to HCV infection, but virus production was significantly decreased compared with cells in which the LDLR activity had been corrected to normal levels (PMID 31358055). Sources: Literature |
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