| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Viral resistance v0.49 | MX1 | Ivone Leong Publications for gene: MX1 were set to 3162334; 14872030; 21935451; https://doi.org/10.1101/2020.05.04.07591 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.48 | MX1 | Ivone Leong Classified gene: MX1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.48 | MX1 | Ivone Leong Added comment: Comment on list classification: PMID: 30696001 fused a cell penetrating peptide to the C-terminus of the Mx1 protein and found that it inhibited viral replication and viral RNA expression in infected cells. Administration of this fused protein improved the survival of mice infected with PR8 influenza viral strain. The paper suggests that this fused protein could be used as a therapeutic agent. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.48 | MX1 | Ivone Leong Gene: mx1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.40 | MX1 |
Sarah Leigh gene: MX1 was added gene: MX1 was added to Viral resistance. Sources: Literature Mode of inheritance for gene: MX1 was set to Unknown Publications for gene: MX1 were set to 3162334; 14872030; 21935451; https://doi.org/10.1101/2020.05.04.07591 Review for gene: MX1 was set to AMBER Added comment: MX1 is an interferon-induced protein with antiviral activity (PMID 3162334). PMID 14872030 c.-88G>T was more frequent in 40 unrelated Japanese patients with subacute sclerosing panencephalitisis (associated with CNS infection with measles virus), than in 90 controls (0.42 in patients vs 0.29 in controls). Variant c.-88G>T results increased MX1 expression, the authors suggest that MX1 may paradoxically enable persistence of the virus in the CNS by attenuating viral gene expression and preventing complete immunologic clearance. PMID 21935451 concluded that genetic variation in the interferon response pathway is associated with risk for symptomatic West Nile viru infection and disease progression. Preprint https://doi.org/10.1101/2020.05.04.075911 Reports that rs35074065 of TMPRSS2 results in increased expression of the nearby gene MX1. Sources: Literature |
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