| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Viral resistance v0.26 | TLR3 | Ivone Leong Publications for gene: TLR3 were set to 20636339 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.25 | TLR3 | Ivone Leong Mode of inheritance for gene: TLR3 was changed from to Unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.24 | TLR3 | Ivone Leong Classified gene: TLR3 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.24 | TLR3 |
Ivone Leong Added comment: Comment on list classification: PMID: 22174453 and 23962581 found that rs3775291 (Leu412Phe) confers resistance to HIV-1 infection in Spanish and Estonian HIV-1 exposed seronegative i.v. drug users. PMID: 20636339 found that activating TLR3 inhibits HIV replication and that TLR3-mediated induction of multiple anti-HIV factors (i.e. type I interferon inducible antiviral factors - APOBEC3G and tetherin) should be beneficial for HIV treatment. Therefore, there is enough evidence to promote this gene to Green status. |
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| Viral resistance v0.24 | TLR3 | Ivone Leong Gene: tlr3 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.20 | TLR3 |
Sarah Leigh gene: TLR3 was added gene: TLR3 was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: TLR3 was set to Publications for gene: TLR3 were set to 20636339 Phenotypes for gene: TLR3 were set to {HIV1 infection, resistance to} 609423 |
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