MT-ND1

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
OMIM: 516000, Gene2Phenotype

11 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 11 panels
Green MT-ND1 in Leber hereditary optic neuropathy Level 2: Mitochondrial Version 2.10 Latest signed off version: v2.5 (22 Mar 2023)	review	MITOCHONDRIAL	Sources Expert List Expert Review Green Phenotypes Leber's hereditary optic neuropathy External ophthalmoplegia Optic neuropathy and nystagmus Tags gene-checked
No list MT-ND1 in Sudden death in young people Level 3: Cardiac arrhythmia Level 2: Cardiovascular disorders Version 1.16	review	MITOCHONDRIAL	Sources Expert Review Removed Literature Other Phenotypes Sudden infant death syndrome, 272120 SIDS SIDS sudden infant death syndrome, 272120, Tags curated_removed
Green MT-ND1 in Structural basal ganglia disorders Level 3: Motor Disorders of the CNS Level 2: Neurology and neurodevelopmental disorders Version 1.40	review	MITOCHONDRIAL	Sources Expert Review Green Literature Tags gene-checked
Green MT-ND1 in Optic neuropathy Level 2: Ophthalmology Version 5.48 Latest signed off version: v5.0 (30 Apr 2025)	review	MITOCHONDRIAL	Sources London North GLH Expert Review Green UKGTN Phenotypes Optic neuropathy and nystagmus External ophthalmoplegia Leber's hereditary optic neuropathy Tags gene-checked
Green MT-ND1 in Undiagnosed metabolic disorders Level 3: Specific metabolic abnormalities Level 2: Metabolic disorders Version 1.642	review	MITOCHONDRIAL	Sources Expert Review Green Phenotypes LEBER OPTIC ATROPHY SUDDEN INFANT DEATH SYNDROME MITOCHONDRIAL COMPLEX I DEFICIENCY DYSTONIA, ADULT-ONSET MELAS SYNDROME DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL Tags gene-checked
Green MT-ND1 in Likely inborn error of metabolism Level 2: Metabolic Version 8.91 Latest signed off version: v8.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders Unexplained death in infancy and sudden unexplained death in childhood	review	MITOCHONDRIAL	Sources Expert Review Green Phenotypes MELAS SYNDROME MITOCHONDRIAL COMPLEX I DEFICIENCY LEBER OPTIC ATROPHY DYSTONIA, ADULT-ONSET DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL SUDDEN INFANT DEATH SYNDROME Tags gene-checked
Red MT-ND1 in Intellectual disability Level 2: Developmental disorders Version 9.279 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	MITOCHONDRIAL	Sources Expert Review Red Expert Review Amber BRIDGE study SPEED NEURO Tier1 Gene Phenotypes Leber optic atrophy Sudden infant death syndrome Mitochondrial complex I deficiency Dystonia, adult-onset Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes syndrome MELAS syndrome Deafness, nonsyndromic sensorineural, mitochondrial
Green MT-ND1 in Mitochondrial disorders Level 2: Mitochondrial Version 9.41 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy	review	MITOCHONDRIAL	Sources Expert Review Green UKGTN Phenotypes LEBER OPTIC ATROPHY SUDDEN INFANT DEATH SYNDROME MITOCHONDRIAL COMPLEX I DEFICIENCY DYSTONIA, ADULT-ONSET MELAS SYNDROME DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL Tags gene-checked
Red MT-ND1 in Retinal disorders Level 2: Ophthalmology Version 8.86 Latest signed off version: v8.0 (30 Apr 2025)	review	MITOCHONDRIAL	Sources NHS GMS Expert Review Red
Red MT-ND1 in Adult onset dystonia, chorea or related movement disorder Level 2: Neurology Version 5.3 Latest signed off version: v5.0 (30 Apr 2025)	review	MITOCHONDRIAL	Sources Expert Review Red NHS GMS London North GLH
No list MT-ND1 in Childhood onset dystonia, chorea or related movement disorder Level 2: Neurology Version 7.13 Latest signed off version: v7.0 (30 Apr 2025)	review	MITOCHONDRIAL	Sources Expert Review Removed London North GLH Phenotypes MITOCHONDRIAL COMPLEX I DEFICIENCY, MITOCHONDRIAL TYPE 3 Tags curated_removed