1. Genes and Genomic Entities
  2. MT-ND5

MT-ND5

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
OMIM: 516005, Gene2Phenotype

7 panels

Panel Reviews Mode of inheritance Details
7 panels
No list MT-ND5 in Hypertrophic cardiomyopathy


Level 2: Cardiology
Version 5.29
Latest signed off version: v5.0 (30 Apr 2025)

Component of the following Super Panels:

  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MITOCHONDRIAL
    Sources
    • Expert Review Removed
    • Literature
    Phenotypes
    • hypertrophic cardiomyopathy, MONDO:0005045
    Tags
    • curated_removed
    Amber MT-ND5 in Optic neuropathy


    Level 2: Ophthalmology
    Version 5.48
    Latest signed off version: v5.0 (30 Apr 2025)

    		review MITOCHONDRIAL
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Leber hereditary optic neuropathy, MONDO:0010788
    Tags
    • technical-limitations
    Green MT-ND5 in Undiagnosed metabolic disorders

    Level 3: Specific metabolic abnormalities
    Level 2: Metabolic disorders
    Version 1.642

    		review MITOCHONDRIAL
    Sources
    • Expert Review Green
    Phenotypes
    • LEBER OPTIC ATROPHY
    • LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY
    • MELAS SYNDROME
    • MERRF SYNDROME
    Tags
    • gene-checked
    Green MT-ND5 in Likely inborn error of metabolism


    Level 2: Metabolic
    Version 8.91
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MITOCHONDRIAL
    Sources
    • Expert Review Green
    Phenotypes
    • MELAS SYNDROME
    • LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY
    • LEBER OPTIC ATROPHY
    • MERRF SYNDROME
    Tags
    • gene-checked
    Green MT-ND5 in Mitochondrial disorders


    Level 2: Mitochondrial
    Version 9.41
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy

    		•  review MITOCHONDRIAL
    Sources
    • Expert Review Green
    • UKGTN
    Phenotypes
    • LEBER OPTIC ATROPHY
    • LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY
    • MELAS SYNDROME
    • LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY
    • MERRF SYNDROME
    Tags
    • gene-checked
    Amber MT-ND5 in Paediatric or syndromic cardiomyopathy


    Level 2: Cardiology
    Version 7.96
    Latest signed off version: v7.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MITOCHONDRIAL
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • hypertrophic cardiomyopathy, MONDO:0005045
    Tags
    • Q2_25_ promote_green
    • Q3_25_expert_review
    • Q3_25_NHS_review
    No list MT-ND5 in Childhood onset dystonia, chorea or related movement disorder


    Level 2: Neurology
    Version 7.13
    Latest signed off version: v7.0 (30 Apr 2025)

    		review MITOCHONDRIAL
    Sources
    • Expert Review Removed
    • London North GLH
    Phenotypes
    • Leber Optic Atrophy And Dystonia
    Tags
    • curated_removed