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Congenital muscular dystrophy and congenital myopathy

Gene: DMD

Green List (high evidence)

DMD (dystrophin)
EnsemblGeneIds (GRCh38): ENSG00000198947
EnsemblGeneIds (GRCh37): ENSG00000198947
OMIM: 300377, Gene2Phenotype
DMD is in 19 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Added the tag ‘gene-therapy-trial’ as this gene-disease is within the Gene Therapy Panel available here: https://panelapp.genomicsengland.co.uk/panels/412
Created: 14 May 2018, 9:35 a.m.
Comment when marking as ready: Expert review green, confirmed DD gene and >3 cases reported.
Created: 11 Jan 2017, 12:23 p.m.
Comment on mode of inheritance: Hemizygous in Gene2Phenotype.
Created: 11 Jan 2017, 12:21 p.m.

Emma Clement (Great Ormond Street Hospital)

Green List (high evidence)

Phenotypes
Duchenne muscular dystrophy, 310200Becker muscular dystrophy, 300376Cardiomyopathy, dilated, 3B, 302045; Duchenne or Becker muscular dystrophy

History Filter Activity

3 Feb 2023, Gel status: 3

Created, Added New Source, Added Tag, Set mode of inheritance, Set Phenotypes, Set penetrance

Arina Puzriakova (Genomics England Curator)

gene: DMD was added gene: DMD was added to Congenital muscular dystrophy and congenital myopathy. Sources: NHS GMS,UKGTN,Emory Genetics Laboratory,Expert Review Green,Radboud University Medical Center, Nijmegen gene-therapy-trial, Skewed X-inactivation tags were added to gene: DMD. Mode of inheritance for gene: DMD was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females Phenotypes for gene: DMD were set to Becker muscular dystrophy, OMIM:300376; Duchenne muscular dystrophy, OMIM:310200 Penetrance for gene: DMD were set to Complete