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Hearing loss

Gene: MYO1A

Red List (low evidence)

MYO1A (myosin IA)
EnsemblGeneIds (GRCh38): ENSG00000166866
EnsemblGeneIds (GRCh37): ENSG00000166866
OMIM: 601478, Gene2Phenotype
MYO1A is in 1 panel

3 reviews

Jun Shen (Harvard Medical School)

Red List (low evidence)

MYO1A is not associated with a phenotype entry in OMIM.
Created: 9 Feb 2016, 10:07 a.m.
MYO1A is not associated with a phenotype entry in OMIM.
Created: 7 Feb 2016, 3:44 p.m.

Publications

Damian Smedley (Genomics England Curator)

Comment on list classification: Recent study (24616153) provided evidence that not associated with deafness contrary to earlier suggestions. Panels probably predated this 2014 paper
Created: 29 Jan 2016, 4:03 p.m.
Comment on list classification: Based on expert review and no evidence for involvement in OMIM or G2P
Created: 29 Jan 2016, 3:59 p.m.

Maria Bitner-Glindzicz (UCL)

Red List (low evidence)

Very unlikely to cause deafness
Created: 30 Sep 2015, 2:56 p.m.

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Red
  • Radboud University Medical Center, Nijmegen
  • Expert
  • Emory Genetics Laboratory
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • hearing loss
  • Nonsyndromic Hearing Loss, Dominant
  • Deafness, autosomal dominant 48, 607841
  • Deafness,autosomaldominant48,607841
OMIM
601478
Clinvar variants
Variants in MYO1A
Penetrance
Complete
Panels with this gene

History Filter Activity

29 Jan 2016, Gel status: 1

Gene classified by Genomics England curator

Damian Smedley (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

29 Jan 2016, Gel status: 1

Gene classified by Genomics England curator

Damian Smedley (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

24 Jun 2015, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MYO1A was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

24 Jun 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

MYO1A was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,UKGTN,Emory Genetics Laboratory,Expert,Radboud University Medical Center, Nijmegen

24 Jun 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MYO1A was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

24 Jun 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

MYO1A was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,UKGTN,Emory Genetics Laboratory,Expert,Radboud University Medical Center, Nijmegen

24 Jun 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MYO1A was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

24 Jun 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

MYO1A was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,UKGTN,Emory Genetics Laboratory,Expert,Radboud University Medical Center, Nijmegen

24 Jun 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MYO1A was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

24 Jun 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

MYO1A was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,UKGTN,Emory Genetics Laboratory,Expert,Radboud University Medical Center, Nijmegen

24 Jun 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

MYO1A was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,UKGTN,Emory Genetics Laboratory,Expert,Radboud University Medical Center, Nijmegen