Monogenic hearing loss
Gene: TECTA
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Phenotypes
#601543:Deafness, autosomal dominant 8/12[Hearing loss, sensorineuralAffects mid- to high-frequenciesU-shaped audiogram]; #603629:Deafness, autosomal recessive 21[Hearing loss, severe-to-profound (70-110 dB on all frequencies, most pronounced in mid-frequencies)]
Publications
Comment when marking as ready: Expert review and OMIM confirmedCreated: 29 Jan 2016, 5:20 p.m.
Comment on mode of inheritance: OMIM confirms AD and ARCreated: 29 Jan 2016, 5:20 p.m.
New review confirms gene status and mode of inheritance; no changes required.Created: 1 Jun 2018, 2:40 p.m.
Both recessive and dominant forms of nonsyndromic hearing loss are reported by Illumina for this gene.Created: 2 Jul 2015, 7:57 a.m.
Phenotypes for TECTA were set to hearing loss; Nonsyndromic Hearing Loss, Dominant; Deafness, autosomal dominant 8/12, 601543; Nonsyndromic Hearing Loss, Recessive; Nonsyndromic Hearing Loss, Dominant; #603629:Deafness, autosomal recessive 21
Publications for TECTA were set to PMID: 10196713; 10987647; 11087000; 11333869; 12162770; 12746400; 15995703; 16718611; 17431902; 17661817; 18575463; 6971620; 9079715; 9503015; 9590290; 9718342; 9949200
This gene has been classified as Green List (High Evidence).
Mode of inheritance for TECTA was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene TECTA was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
TECTA was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN,Radboud University Medical Center, Nijmegen,Expert
Model of inheritance for gene TECTA was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
TECTA was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN,Radboud University Medical Center, Nijmegen,Expert
Model of inheritance for gene TECTA was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
TECTA was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN,Radboud University Medical Center, Nijmegen,Expert
Model of inheritance for gene TECTA was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
TECTA was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN,Radboud University Medical Center, Nijmegen,Expert
TECTA was added to Congenital hearing impairment (Profound/Severe)panel. Sources: Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN,Radboud University Medical Center, Nijmegen,Expert