- Panels
- Monogenic hearing loss
- NCOA3
Genes in panel
- ABHD12 3
- ACTG1 4
- ADGRV1 6
- AIFM1 2
- ALMS1 3
- AP1S1 2
- ATP11A 1
- ATP2B2 5
- ATP6V1B1 6
- ATP6V1B2 1
- BCS1L 4
- BSND 3
- CABP2 3
- CCDC50 6
- CDC14A 2
- CDH23 5
- CEACAM16 6
- CEP250 2
- CEP78 1
- CHD7 3
- CIB2 5
- CISD2 3
- CLDN14 5
- CLDN9 5
- CLPP 5
- CLRN1 5
- COCH 7
- COL11A1 3
- COL11A2 4
- COL2A1 3
- COL4A5 3
- COL9A1 3
- COL9A2 2
- COL9A3 6
- CRLS1 1
- CRYM 7
- DAP3 2
- DFNA5 6
- DFNB59 6
- DIAPH1 5
- DMXL2 4
- DNAJC3 1
- DNMT1 5
- DSPP 3
- EDN3 6
- EDNRB 6
- EPS8 3
- EPS8L2 2
- ESPN 4
- ESRRB 5
- EYA1 6
- EYA4 5
- FDXR 2
- FGF3 3
- FOXI1 7
- GATA3 4
- GGPS1 3
- GIPC3 5
- GJB2 6
- GJB6 8
- GPR156 2
- GPSM2 5
- GREB1L 3
- GRHL2 5
- GRXCR1 5
- GRXCR2 3
- HAAO 1
- HARS2 7
- HGF 7
- HOXA2 3
- HSD17B4 5
- ILDR1 5
- KARS 6
- KCNE1 5
- KCNJ10 4
- KCNJ16 2
- KCNQ1 5
- KCNQ4 5
- KIAA1024L 1
- KIT 4
- LARS2 5
- LETM1 3
- LHFPL5 5
- LHX3 3
- LMX1A 4
- LOXHD1 5
- LRTOMT 5
- MARVELD2 5
- MASP1 4
- MITF 6
- MN1 2
- MPZL2 2
- MRPL49 2
- MSRB3 5
- MT-RNR1 4
- MT-TS1 3
- MYH14 5
- MYH9 5
- MYO15A 6
- MYO3A 6
- MYO6 5
- MYO7A 5
- NLRP12 1
- OGDHL 3
- OPA1 3
- OSBPL2 3
- OTOA 5
- OTOF 5
- OTOG 5
- OTOGL 3
- P2RX2 6
- PAX2 3
- PAX3 5
- PBX1 3
- PCDH15 5
- PDZD7 4
- PKHD1L1 2
- PLS1 2
- PLXNB2 2
- PNPT1 3
- POU3F4 5
- POU4F3 5
- PRPS1 5
- PSMC3 1
- PTPRQ 6
- RDX 5
- RFC4 2
- RNF220 3
- S1PR2 3
- SALL1 3
- SALL4 3
- SERAC1 2
- SERPINB6 5
- SGPL1 1
- SIX1 5
- SLC12A2 4
- SLC17A8 6
- SLC26A4 5
- SLC26A5 5
- SLC4A11 3
- SLC52A2 3
- SLC52A3 2
- SLITRK6 3
- SMPX 5
- SOX10 5
- SPATA5 2
- SPATA5L1 4
- STRC 5
- SYNE4 3
- TBC1D24 2
- TECTA 5
- TIMM8A 4
- TMC1 5
- TMIE 5
- TMPRSS3 5
- TPRN 5
- TRIOBP 5
- TUBB4B 2
- USH1C 5
- USH1G 5
- USH2A 5
- USP48 2
- WFS1 5
- WHRN 6
- XPA 3
- ABCC1 2
- ACOX1 1
- AP1B1 1
- ARSG 1
- ATOH1 3
- CLIC5 5
- CLRN2 2
- COG4 2
- COL4A6 6
- DHRSX 6
- DIABLO 5
- DIAPH3 5
- ELMOD3 3
- ESRP1 2
- FOXF2 2
- GJB3 6
- HOMER2 2
- KDM3B 4
- KIAA0391 1
- KITLG 4
- MET 1
- MIR96 4
- MORC2 2
- MT-CO1 4
- MT-TK 3
- MT-TL1 4
- MT-TS2 3
- NARS2 3
- NTN1 3
- OXR1 1
- PDSS1 1
- PLCG1 2
- PMP22 3
- PPIP5K2 2
- PTRH2 1
- RIPOR2 8
- ROR1 2
- SNAI2 5
- SOX2 6
- SPATC1L 2
- SPNS2 2
- SPTBN4 1
- STX4 1
- STXBP3 4
- TBX2 1
- THOC1 2
- TMTC2 2
- TNC 3
- TOP2B 2
- WBP2 2
- YARS 1
- ABHD5 1
- ABR 2
- ACAN 2
- ACTB 1
- ADCY1 1
- ALDH1A2 1
- AP3D1 2
- APAF1 2
- APOPT1 2
- AQP4 2
- ARSB 1
- ATF2 2
- ATP1A2 2
- ATP6V0A4 1
- ATP8B1 2
- AXIN1 2
- BARHL1 2
- BBS1 1
- BBS4 1
- BCAP31 2
- BCR 1
- BDNF 2
- BDP1 5
- BLOC1S5 1
- BLOC1S6 1
- BMP4 2
- BSN 2
- BTD 1
- CACNA1D 1
- CACNB2 2
- CACNG2 2
- CASP3 2
- CATSPER2 2
- CD151 1
- CD164 2
- CDKN1B 2
- CDKN2D 2
- CELSR1 2
- CHRNA9 2
- CKB 2
- CLDN11 2
- CLNS1A 2
- CNRIP1 1
- COL4A3 1
- COL4A4 1
- CPLX1 2
- DACT1 1
- DDB2 2
- DDR1 2
- DIO2 2
- DIO3 2
- DLX2 2
- DLX5 2
- DMD 2
- DVL1 2
- DVL2 2
- DVL3 2
- EPHA10 1
- EPHB1 2
- EPHB2 2
- EPHB3 2
- ERAL1 1
- ERBB4 2
- ERCC1 2
- ERCC2 2
- ERCC3 2
- ERCC4 2
- ERCC5 2
- ESR2 2
- FABP4 2
- FAS 2
- FBXO2 2
- FGFR1 3
- FGFR2 2
- FGFR3 1
- FIGN 2
- FKBP14 1
- FOXC1 1
- FOXG1 2
- FZD3 2
- FZD6 2
- GBX2 2
- GFER 1
- GFI1 2
- GJA1 2
- GJA1P1 3
- GJB1 2
- GJB4 2
- GJB5 2
- GLI3 2
- GOSR2 1
- GPX1 2
- GRAP 2
- GRID1 1
- GSTM1 1
- GSTP1 1
- GSTT1 2
- GUSB 1
- HAL 1
- HARS 6
- HES1 1
- HES5 1
- HMX2 1
- HMX3 1
- HOXA1 1
- HOXB1 1
- HTRA2 3
- IFT88 1
- IGF1 1
- ITGA8 1
- JAG1 1
- JAG2 1
- KCNMA1 2
- LAMA2 1
- LARGE1 2
- LFNG 1
- LMO4 1
- LRIG3 1
- LRP2 1
- MAFB 1
- MAP1A 1
- MCOLN3 1
- MIR182 1
- MIR183 2
- MKKS 1
- MOS 1
- MPV17 1
- MSX2 1
- MTAP 1
- MYO1C 1
- MYO1F 1
- NAV2 1
- NCOA3 1
- NDP 1
- NEU1 1
- NEUROD1 1
- NEUROG1 1
- NF1 1
- NLRP3 1
- NOTCH1 1
- NOX3 1
- NOXO1 1
- NR2F1 1
- NR4A3 1
- NTF3 1
- NTRK2 1
- NTRK3 1
- OC90 1
- OTOP1 1
- OTOR 1
- OTX1 1
- OTX2 1
- PET100 1
- PHEX 1
- PIK3C2A 1
- PITX2 1
- PLEK 1
- PNOC 1
- POLD1 2
- POLH 1
- POLR1C 1
- POLR1D 1
- POU1F1 1
- PPP3R1 1
- PROP1 1
- PRRX1 1
- PRRX2 1
- PTK7 1
- RARA 1
- RARB 1
- RARG 1
- RASA1 1
- RPGR 5
- RPS6KA3 1
- SARS 2
- SCARB2 1
- SCD5 2
- SCRIB 1
- SDHD 1
- SIX5 6
- SLC12A6 1
- SLC12A7 1
- SLC19A2 1
- SLC1A3 1
- SLC29A3 3
- SLC30A4 1
- SLC33A1 1
- SLC4A7 1
- SLC9A1 1
- SMS 1
- SOBP 1
- SOD1 1
- SOX9 1
- SPINK5 1
- SPRY2 1
- ST3GAL5 1
- SYNJ2 1
- TBL1X 1
- TBX1 1
- TBX10 1
- TCF21 1
- TCOF1 1
- TGFA 1
- TGFB2 1
- THRA 1
- THRB 1
- TJP2 5
- TMEM132E 1
- TMPRSS5 1
- TNFRSF11B 1
- TRMU 1
- TRPV4 1
- TSHR 1
- TSPEAR 3
- TUB 1
- TYRP1 1
- UCN 1
- VANGL2 1
- XPC 1
- YAP1 1
- ZPR1 2
- MYO1A 5
STRs in panel
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Monogenic hearing loss
Gene: NCOA3 Red List (low evidence)
NCOA3 (nuclear receptor coactivator 3)
EnsemblGeneIds (GRCh38): ENSG00000124151
EnsemblGeneIds (GRCh37): ENSG00000124151
OMIM: 601937, Gene2Phenotype
NCOA3 is in 1 panel
EnsemblGeneIds (GRCh38): ENSG00000124151
EnsemblGeneIds (GRCh37): ENSG00000124151
OMIM: 601937, Gene2Phenotype
NCOA3 is in 1 panel
1 review
Eleanor Williams (Genomics England Curator)
Red List (low evidence)
PMID: 33326993 - Salazar da Silva et al 2020 - report a 5 generation Brazilian family with 15 individuals with non-syndromic, bilateral and progressive hearing loss. Using linkage analysis and then exome sequencing they identified a heterozygous variant in NCOA3 (NM_181659, c.2810C > G; p.Ser937Cys) that was found in the 7 analysed affected individuals. It was also found in 4 unaffected individuals but they are within the range of onset of hearing loss observed in the family. Expression of nco3 was found in the inner ear of mice and zebrafish. ncoa3-/- zebrafish showed subtle alterations in cartilage, mineral density and abnormal adult swimming behaviour, which may suggest the mechanism of pathogenicity.
Sources: LiteratureCreated: 11 Feb 2021, 6:36 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
non-syndromic hearing loss
Publications
Created: 11 Feb 2021, 6:36 p.m.
Panel version: 2.149
Panel version: 2.149
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- Literature
- Phenotypes
-
- non-syndromic hearing loss
- OMIM
- 601937
- Clinvar variants
- Variants in NCOA3
- Penetrance
- None
- Publications
- Panels with this gene
History Filter Activity
11 Feb 2021, Gel status: 1
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes
Eleanor Williams (Genomics England Curator)gene: NCOA3 was added gene: NCOA3 was added to Hearing loss. Sources: Literature Mode of inheritance for gene: NCOA3 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: NCOA3 were set to 33326993 Phenotypes for gene: NCOA3 were set to non-syndromic hearing loss Review for gene: NCOA3 was set to RED