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  2. Embryonal tumour of possible germline origin
  3. WT1
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Embryonal tumour of possible germline origin

Gene: WT1

Green List (high evidence)
WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 18 panels

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Green List (high evidence)

WT1 has been added to the panel for the clinical indication 'R456 Embryonal tumour of possible germline origin' with a green rating as agreed with the NHS Genomic Medicine Service.
Created: 26 Jan 2026, 6:10 p.m. | Last Modified: 26 Jan 2026, 6:10 p.m.
Panel Version: 0.7
Comment on phenotypes: This gene has been associated with relevant phenotypes in OMIM (MIMs #136680, #194070 & #194080) and the OMIM records were last accessed on 30 December 2025.
Created: 30 Dec 2025, 11:14 a.m. | Last Modified: 30 Dec 2025, 11:14 a.m.
Panel Version: 0.2

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Frasier syndrome, OMIM:136680; Denys-Drash syndrome, OMIM:194080; Wilms tumor 1, MONDO:0008679; Frasier syndrome, MONDO:0007635; Denys-Drash syndrome, MONDO:0008682; Wilms tumor, type 1, OMIM:194070

Created: 30 Dec 2025, 11:14 a.m.
Last Modified: 30 Dec 2025, 11:14 a.m.
Panel version: 0.7

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Frasier syndrome, OMIM:136680
  • Wilms tumor, type 1, OMIM:194070
  • Wilms tumor 1, MONDO:0008679
  • Frasier syndrome, MONDO:0007635
  • Denys-Drash syndrome, OMIM:194080
  • Denys-Drash syndrome, MONDO:0008682
OMIM
607102
Clinvar variants
Variants in WT1
Penetrance
None
Panels with this gene

History Filter Activity

30 Dec 2025, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

gene: WT1 was added gene: WT1 was added to Embryonal tumour of possible germline origin. Sources: NHS GMS,Expert Review Green Mode of inheritance for gene: WT1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: WT1 were set to Frasier syndrome, OMIM:136680; Wilms tumor, type 1, OMIM:194070; Wilms tumor 1, MONDO:0008679; Frasier syndrome, MONDO:0007635; Denys-Drash syndrome, OMIM:194080; Denys-Drash syndrome, MONDO:0008682