Familial Tumours Syndromes of the central & peripheral Nervous system

Gene: LZTR1

Green List (high evidence)

LZTR1 (leucine zipper like transcription regulator 1)
EnsemblGeneIds (GRCh38): ENSG00000099949
EnsemblGeneIds (GRCh37): ENSG00000099949
OMIM: 600574, Gene2Phenotype
LZTR1 is in 15 panels

2 reviews

D Gareth Evans (UoM)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Ellen Thomas (Genomics England Curator)

Comment on list classification: Germline predisposition to familial shwannomatosis
Created: 15 Feb 2016, 12:48 p.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • {Schwannomatosis-2, susceptibility to}, 615670
  • (originally on Familial schwannomatosis gene panel)
  • familial schwannomatosis
OMIM
600574
Clinvar variants
Variants in LZTR1
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

15 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

15 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

15 Feb 2016, Gel status: 1

Set publications

Ellen Thomas (Genomics England Curator)

Publications for LZTR1 were set to PubMed: 24362817

9 Oct 2015, Gel status: 1

Set Mode of Inheritance

D Gareth Evans (UoM)

Model of inheritance for gene LZTR1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

9 Oct 2015, Gel status: 1

Added New Source

D Gareth Evans (UoM)

LZTR1 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: UKGTN

27 Aug 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

LZTR1 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Radboud University Medical Center, Nijmegen