Familial Tumours Syndromes of the central & peripheral Nervous system

Gene: VHL

Green List (high evidence)

VHL (von Hippel-Lindau tumor suppressor)
EnsemblGeneIds (GRCh38): ENSG00000134086
EnsemblGeneIds (GRCh37): ENSG00000134086
OMIM: 608537, Gene2Phenotype
VHL is in 25 panels

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History Filter Activity

2 Aug 2021, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: VHL were changed from Von Hippel-Lindau Syndrome; von Hippel-Lindau syndrome, 193300; Renal cell carcinoma, somatic, 144700; Pheochromocytoma, 171300; Hemangioblastoma, cerebellar, somatic; Erythrocytosis, familial, 2, 263400 to von Hippel-Lindau syndrome, OMIM:193300; Pheochromocytoma, OMIM:171300; Hemangioblastoma, cerebellar, somatic

15 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

15 Feb 2016, Gel status: 3

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for VHL was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

27 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene VHL was set to Unknown

27 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Eligibility statement prior genetic testing

27 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene VHL was set to Unknown

27 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Radboud University Medical Center, Nijmegen

27 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene VHL was set to Unknown

27 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: UKGTN

27 Aug 2015, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene VHL was set to Unknown

27 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Illumina TruGenome Clinical Sequencing Services

12 Aug 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Eligibility statement prior genetic testing

22 Jul 2015, Gel status: 3

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene VHL was changed to Unknown

22 Jul 2015, Gel status: 3

Added New Source

Eik Haraldsdottir (Genomics England)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Radboud University Medical Center, Nijmegen

22 Jul 2015, Gel status: 2

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene VHL was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

22 Jul 2015, Gel status: 2

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene VHL was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

22 Jul 2015, Gel status: 2

Added New Source

Eik Haraldsdottir (Genomics England)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: UKGTN

22 Jul 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

VHL was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Illumina TruGenome Clinical Sequencing Services