Familial Tumours Syndromes of the central & peripheral Nervous system

Gene: NF2

Green List (high evidence)

NF2 (neurofibromin 2)
EnsemblGeneIds (GRCh38): ENSG00000186575
EnsemblGeneIds (GRCh37): ENSG00000186575
OMIM: 607379, Gene2Phenotype
NF2 is in 10 panels

2 reviews

Ellen Thomas (Genomics England Curator)

Comment on list classification: Eligibility criteria have been modified to exclude sporadic cases on the basis of evidence presented by Gareth Evans.
Created: 15 Feb 2016, 12:39 p.m.

D Gareth Evans (UoM)

Green List (high evidence)

I am really concerned that including sporadic cases will mean including almost entirely mosaic NF2 cases or even chance occurrences
Created: 9 Oct 2015, 10:39 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • Expert list
  • Radboud University Medical Center, Nijmegen
  • UKGTN
  • Emory Genetics Laboratory
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • Neurofibromatosis, Type 2
  • Brain, CNS, and PNS Cancer
  • Neurofibromatosis, Type II
  • Neurofibromatosis, type 2, 101000
  • Meningioma, NF2-related, somatic, 607174
  • Schwannomatosis, 162091
  • (originally on Familial schwannomatosis gene panel)
OMIM
607379
Clinvar variants
Variants in NF2
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

15 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

15 Feb 2016, Gel status: 4

Set publications

Ellen Thomas (Genomics England Curator)

Publications for NF2 were set to PMID: 25725045; PMID: 19880713

15 Feb 2016, Gel status: 4

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

15 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Eligibility statement prior genetic testing

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Expert list

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Radboud University Medical Center, Nijmegen

27 Aug 2015, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene NF2 was set to Unknown

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Eligibility statement prior genetic testing

27 Aug 2015, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene NF2 was set to Unknown

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Radboud University Medical Center, Nijmegen

27 Aug 2015, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene NF2 was set to Unknown

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: UKGTN

27 Aug 2015, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene NF2 was set to Unknown

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Emory Genetics Laboratory

27 Aug 2015, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene NF2 was set to Unknown

27 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Illumina TruGenome Clinical Sequencing Services

12 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Eligibility statement prior genetic testing

22 Jul 2015, Gel status: 4

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene NF2 was changed to Unknown

22 Jul 2015, Gel status: 4

Added New Source

Eik Haraldsdottir (Genomics England)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Radboud University Medical Center, Nijmegen

22 Jul 2015, Gel status: 3

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

22 Jul 2015, Gel status: 3

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

22 Jul 2015, Gel status: 3

Added New Source

Eik Haraldsdottir (Genomics England)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: UKGTN

22 Jul 2015, Gel status: 2

Added New Source

Eik Haraldsdottir (Genomics England)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Emory Genetics Laboratory

22 Jul 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Illumina TruGenome Clinical Sequencing Services