Familial Tumours Syndromes of the central & peripheral Nervous system
Gene: NF2EnsemblGeneIds (GRCh38): ENSG00000186575
EnsemblGeneIds (GRCh37): ENSG00000186575
OMIM: 607379, Gene2Phenotype
NF2 is in 10 panels
2 reviews
Ellen Thomas (Genomics England Curator)
Comment on list classification: Eligibility criteria have been modified to exclude sporadic cases on the basis of evidence presented by Gareth Evans.Created: 15 Feb 2016, 12:39 p.m.
D Gareth Evans (UoM)
I am really concerned that including sporadic cases will mean including almost entirely mosaic NF2 cases or even chance occurrencesCreated: 9 Oct 2015, 10:39 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Eligibility statement prior genetic testing
- Expert list
- Radboud University Medical Center, Nijmegen
- UKGTN
- Emory Genetics Laboratory
- Illumina TruGenome Clinical Sequencing Services
- Phenotypes
-
- Neurofibromatosis, Type 2
- Brain, CNS, and PNS Cancer
- Neurofibromatosis, Type II
- Neurofibromatosis, type 2, 101000
- Meningioma, NF2-related, somatic, 607174
- Schwannomatosis, 162091
- (originally on Familial schwannomatosis gene panel)
- OMIM
- 607379
- Clinvar variants
- Variants in NF2
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Familial tumours of the nervous system
- Bilateral congenital or childhood onset cataracts
- Pigmentary skin disorders
- Familial Tumours Syndromes of the central & peripheral Nervous system
- Adult solid tumours cancer susceptibility
- Mosaic skin disorders - deep sequencing
- Structural eye disease
- Childhood solid tumours cancer susceptibility
- Childhood solid tumours
- Adult solid tumours for rare disease
History Filter Activity
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set publications
Ellen Thomas (Genomics England Curator)Publications for NF2 were set to PMID: 25725045; PMID: 19880713
Set Mode of Inheritance
Ellen Thomas (Genomics England Curator)Mode of inheritance for NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Eligibility statement prior genetic testing
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Expert list
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Radboud University Medical Center, Nijmegen
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene NF2 was set to Unknown
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Eligibility statement prior genetic testing
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene NF2 was set to Unknown
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Radboud University Medical Center, Nijmegen
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene NF2 was set to Unknown
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: UKGTN
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene NF2 was set to Unknown
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Emory Genetics Laboratory
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Model of inheritance for gene NF2 was set to Unknown
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Source: Illumina TruGenome Clinical Sequencing Services
Added New Source
Ellen McDonagh (Genomics England Curator)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Eligibility statement prior genetic testing
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene NF2 was changed to Unknown
Added New Source
Eik Haraldsdottir (Genomics England)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Radboud University Medical Center, Nijmegen
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Added New Source
Eik Haraldsdottir (Genomics England)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: UKGTN
Added New Source
Eik Haraldsdottir (Genomics England)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Emory Genetics Laboratory
Added New Source
Eik Haraldsdottir (Genomics England)NF2 was added to Familial Tumours Syndromes of the central & peripheral Nervous systempanel. Sources: Illumina TruGenome Clinical Sequencing Services