Sarcoma cancer susceptibility
Gene: WRN

WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 17 panels

1 review

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Promoted from Red to Amber, awaiting expert clinical review. This is a Green gene on the Childhood solid tumours cancer susceptibility panel version 1.2 and the Thyroid cancer pertinent cancer susceptibility panel version 1.0 for Werner syndrome. It is a confirmed cancer gene in Gen2Phenotype for Werner syndrome.
Created: 18 Apr 2019, 3:07 p.m.

This gene was requested to be added to this panel by Shazia Mahamdallie (GOSH).
Sources: Expert list
Created: 18 Apr 2019, 2:59 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Werner syndrome 277700

Created: 18 Apr 2019, 2:59 p.m.

Panel version: 1.10

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Amber
Expert list

Phenotypes

Werner syndrome 277700

OMIM

604611

Clinvar variants

Variants in WRN

Penetrance

None

Panels with this gene

History Filter Activity

18 Apr 2019, Gel status: 2

Entity classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

Gene: wrn has been classified as Amber List (Moderate Evidence).

18 Apr 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: WRN was added gene: WRN was added to Sarcoma cancer susceptibility. Sources: Expert list Mode of inheritance for gene: WRN was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: WRN were set to Werner syndrome 277700

Sarcoma cancer susceptibility Gene: WRN