Deafness and congenital structural abnormalities

Gene: WIF1

Red List (low evidence)

WIF1 (WNT inhibitory factor 1)
EnsemblGeneIds (GRCh38): ENSG00000156076
EnsemblGeneIds (GRCh37): ENSG00000156076
OMIM: 605186, Gene2Phenotype
WIF1 is in 1 panel

5 reviews

Muriel Holder (Clinical Genetics, Guy's Hospital)

Red List (low evidence)

Mode of inheritance
Unknown

Mode of pathogenicity
Other

Sarah Leigh (Genomics England Curator)

Not associated with phenotype in OMIM or G2P / DD. No variants reported
Created: 20 Sep 2016, 7:21 a.m.

Mode of inheritance
Unknown

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Red on the Bilateral Microtia Version 1.10 panel.
Created: 12 Sep 2016, 3:02 p.m.

Jun Shen (Harvard Medical School)

Red List (low evidence)

WIF1 is not associated with a phenotype entry in OMIM.
Created: 9 Feb 2016, 5:16 p.m.

Publications

Maria Bitner-Glindzicz (UCL)

Red List (low evidence)

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Expert list
Phenotypes
  • Bilateral Microtia
OMIM
605186
Clinvar variants
Variants in WIF1
Penetrance
Complete
Panels with this gene

History Filter Activity

26 Oct 2016, Gel status: 1

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

26th Oct 2016: the panels Bilateral microtia version 1.10, Ear malformations with hearing impairment version 0.105, and familial hemifacial microsomia version 0.149 gene panels were combined to create this panel. The panel was revised due to expert review, further curation of evidence and internal clinical evaluation. Ready for promotion to version 1.

14 Oct 2016, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

5 Oct 2016, Gel status: 1

Set Mode of Inheritance

Sarah Leigh (Genomics England Curator)

Model of inheritance for gene WIF1 was set to Unknown

5 Oct 2016, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

WIF1 was created by sleigh

5 Oct 2016, Gel status: 1

Added New Source

Sarah Leigh (Genomics England Curator)

WIF1 was added to Deafness and congenital structural abnormalitiespanel. Sources: Expert list,Expert Review Red