Arthrogryposis
Gene: MYH7The rating of this gene has been updated following NHS Genomic Medicine Service approvalCreated: 3 Mar 2022, 3:49 p.m. | Last Modified: 3 Mar 2022, 3:49 p.m.
Panel Version: 3.150
Comment on list classification: This gene will be flagged for review at the next GMS panel update (added 'for-review' tag) as variants are associated with distal myopathy rather than arthrogryposis and therefore MYH7 should be demoted to RED on this panel.Created: 2 Dec 2020, 3:57 p.m. | Last Modified: 2 Dec 2020, 3:57 p.m.
Panel Version: 3.19
I cannot find evidence for association with arthrogryposis either.Created: 31 Mar 2020, 5:22 a.m. | Last Modified: 31 Mar 2020, 5:22 a.m.
Panel Version: 3.3
Comment on mode of inheritance: usually monoalleleicCreated: 16 Jan 2017, 12:05 p.m.
Comment on list classification: Made green after internal discussionCreated: 16 Jan 2017, 12:04 p.m.
Comment on list classification: No evidence of association with arthrogryposisCreated: 22 Dec 2016, 10:03 a.m.
Unable to find evidence of arthrogryposis although listed on the Guy's panel as an arthrogryposis geneCreated: 22 Dec 2016, 10:03 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Laing distal myopathy 160500
Tag for-review was removed from gene: MYH7.
Source Expert Review Red was added to MYH7. Rating Changed from Green List (high evidence) to Red List (low evidence)
Phenotypes for gene: MYH7 were changed from Laing Distal Myopathy; Cardiomyopathy, familial hypertrophic, 1, 192600; Myopathy, myosin storage, autosomal recessive 255160; Myopathy, myosin storage, autosomal dominant 608358 to Laing distal myopathy, OMIM:160500; Laing early-onset distal myopathy, MONDO:0008050
Gene: myh7 has been classified as Green List (High Evidence).
Tag for-review tag was added to gene: MYH7.
16th Jan 2016: This gene panel was extensively revised with the addition of 101 green genes and review by Alice Gardham. Due to this extensive change to the panel, the decision was made to promote it to the next major version, version 2.
Phenotypes for MYH7 were set to Laing Distal Myopathy; Cardiomyopathy, familial hypertrophic, 1, 192600; Myopathy, myosin storage, autosomal recessive 255160; Myopathy, myosin storage, autosomal dominant 608358
Mode of inheritance for MYH7 was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
This gene has been classified as Green List (High Evidence).
This gene has been classified as Amber List (Moderate Evidence).
This gene has been classified as Amber List (Moderate Evidence).
MYH7 was added to Arthrogryposispanel. Source: UKGTN MYH7 was added to Arthrogryposispanel. Source: Illumina TruGenome Clinical Sequencing Services MYH7 was added to Arthrogryposispanel. Source: Radboud University Medical Center, Nijmegen MYH7 was added to Arthrogryposispanel. Source: Expert Model of inheritance for gene MYH7 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
MYH7 was added to Arthrogryposispanel. Sources: Expert list
MYH7 was created by ellenmcdonagh