Amyotrophic lateral sclerosis/motor neuron disease
Gene: ANGComment on list classification: Promoted to green due to presence on the NHNN panel in development.Created: 15 Jun 2016, 1:02 p.m.
Multiple families/cases reported in OMIM for different variants.Created: 13 Jun 2016, 10:36 a.m.
This gene is on the ALS/MND NGS Panel in the UCLH National Hospital for Neurology and Neurosurgery & Institute of Neurology (NHNN) Neurogenetics genetic testing manual.Created: 13 Jun 2016, 9:09 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Promoted to version 1 on 19th December 2016 following external review and internal curation
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
Phenotypes for ANG were set to Amyotrophic Lateral Sclerosis, Dominant; Amyotrophic lateral sclerosis 9, 611895; familial amyotrophic lateral sclerosis (ALS9)
Publications for ANG were set to PMID: 26753798 - meta-analysis reporting that the rs11701 SNP is not associated with ALS; PMID: 26255299 - meta-analysis concluding that the K17I variant increases the risk for ALS and familial ALS but not sporadic ALS in Caucasian patients; PMID: 25907842 - 31 Chinese Han families with familial amyotrophic lateral sclerosis were screened but no ANG gene variants were found, suggesting it is a rare cause of ALS in this population; PMID: 25372031 functional investigation of ANG variants.
Publications for ANG were set to PMID: 26753798 - meta-analysis reporting that the rs11701 SNP is not associated with ALS; PMID: 26255299 - meta-analysis concluding that the K17I variant increases the risk for ALS and familial ALS but not sporadic ALS in Caucasian patients; PMID: 25907842 - 31 Chinese Han families with familial amyotrophic lateral sclerosis were screened but no ANG gene variants were found, suggesting it is a rare cause of ALS in this population.
Publications for ANG were set to PMID: 26753798 - meta-analysis reporting that the rs11701 SNP is not associated with ALS; PMID: 26255299 - meta-analysis concluding that the K17I variant increases the risk for ALS and familial ALS but not sporadic ALS in Caucasian patients; PMID: 25907842 - 31 Chinese Han families with familial amyotrophic lateral sclerosis were screened but no ANG gene variants were found.
Publications for ANG were set to PMID: 26753798 - meta-analysis reporting that the rs11701 SNP is not associated with ALS; PMID: 26255299 - meta-analysis concluding that the K17I variant increases the risk for ALS and familial ALS but not sporadic ALS in Caucasian patients.
Publications for ANG were set to PMID: 26753798 - meta-analysis reporting that the rs11701 SNP is not associated with ALS.
Model of inheritance for gene ANG was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
ANG was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Radboud University Medical Center, Nijmegen
Model of inheritance for gene ANG was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
ANG was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Illumina TruGenome Clinical Sequencing Services
Model of inheritance for gene ANG was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
ANG was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Radboud University Medical Center, Nijmegen
ANG was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Sources: Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen