Amyotrophic lateral sclerosis/motor neuron disease
Gene: VCPComment on list classification: Two families reported in OMIM for two variants. Additional multiple reports published (see publications).Created: 24 Nov 2016, 12:43 p.m.
This gene is on the ALS/MND NGS Panel in the UCLH National Hospital for Neurology and Neurosurgery & Institute of Neurology (NHNN) Neurogenetics genetic testing manual.Created: 13 Jun 2016, 9:17 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
familial amyotrophic lateral sclerosis (ALS14)
Promoted to version 1 on 19th December 2016 following external review and internal curation
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
Phenotypes for VCP were set to Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia, 613954; Amyotrophic Lateral Sclerosis, Dominant; familial amyotrophic lateral sclerosis (ALS14)
Publications for VCP were set to 27178390; 26511028; 25618255; 25492614; 25457024; 23881933
Publications for VCP were set to PMID: 27178390;
Model of inheritance for gene VCP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Expert
Model of inheritance for gene VCP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Illumina TruGenome Clinical Sequencing Services
Model of inheritance for gene VCP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: UKGTN
Model of inheritance for gene VCP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Radboud University Medical Center, Nijmegen
Model of inheritance for gene VCP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Expert
Model of inheritance for gene VCP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: Illumina TruGenome Clinical Sequencing Services
Model of inheritance for gene VCP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Source: UKGTN
VCP was added to Amyotrophic lateral sclerosis/motor neuron diseasepanel. Sources: Radboud University Medical Center, Nijmegen,UKGTN,Illumina TruGenome Clinical Sequencing Services,Expert