Retinal disordersGene: DRAM2
Comment on list classification: Changed rating from Green to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update (added 'for-review' tag).
Created: 20 Oct 2020, 3:08 p.m. | Last Modified: 20 Oct 2020, 3:08 p.m.
Panel Version: 2.21
Unequivocal cause of adult onset macular dysfunction, with numerous publications (3 including families from >5 independent centres) and a number of families diagnosed through GE pilot and main.
Created: 20 Jan 2020, 10:32 a.m. | Last Modified: 20 Jan 2020, 10:32 a.m.
Panel Version: 2.6
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
macular dystrophy; cone-dystrophy; cone-rod dystrophy
The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Created: 8 Mar 2022, 10:06 a.m. | Last Modified: 8 Mar 2022, 10:06 a.m.
Panel Version: 2.243
Comment on list classification: Promoted from Amber to Green based on expert review.
Created: 5 May 2020, 3:19 p.m. | Last Modified: 5 May 2020, 3:19 p.m.
Panel Version: 2.12
Submitted on behalf of the GMS Eye specialist group. These genes are also from RetNet. There is currently not enough evidence to rate these genes Green, therefore they have been given an Amber rating.
Created: 27 Dec 2019, 9:10 a.m. | Last Modified: 27 Dec 2019, 9:10 a.m.
Panel Version: 2.5
Tag for-review was removed from gene: DRAM2.
Source Expert Review Green was added to DRAM2. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: dram2 has been classified as Amber List (Moderate Evidence).
Tag for-review tag was added to gene: DRAM2.
Gene: dram2 has been classified as Green List (High Evidence).
Phenotypes for gene: DRAM2 were changed from to Cone-rod dystrophy 21, 616502; macular dystrophy; cone-dystrophy
Publications for gene: DRAM2 were set to
Mode of inheritance for gene: DRAM2 was changed from to BIALLELIC, autosomal or pseudoautosomal
gene: DRAM2 was added gene: DRAM2 was added to Retinal disorders. Sources: Expert Review Amber,RetNet,NHS GMS Mode of inheritance for gene: DRAM2 was set to