Retinal disordersGene: DRAM2
Unequivocal cause of adult onset macular dysfunction, with numerous publications (3 including families from >5 independent centres) and a number of families diagnosed through GE pilot and main.
Created: 20 Jan 2020, 10:32 a.m. | Last Modified: 20 Jan 2020, 10:32 a.m.
Panel Version: 2.6
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
macular dystrophy; cone-dystrophy; cone-rod dystrophy
Comment on list classification: Promoted from Amber to Green based on expert review.
Created: 5 May 2020, 3:19 p.m. | Last Modified: 5 May 2020, 3:19 p.m.
Panel Version: 2.12
Submitted on behalf of the GMS Eye specialist group. These genes are also from RetNet. There is currently not enough evidence to rate these genes Green, therefore they have been given an Amber rating.
Created: 27 Dec 2019, 9:10 a.m. | Last Modified: 27 Dec 2019, 9:10 a.m.
Panel Version: 2.5
Gene: dram2 has been classified as Green List (High Evidence).
Phenotypes for gene: DRAM2 were changed from to Cone-rod dystrophy 21, 616502; macular dystrophy; cone-dystrophy
Publications for gene: DRAM2 were set to
Mode of inheritance for gene: DRAM2 was changed from to BIALLELIC, autosomal or pseudoautosomal
gene: DRAM2 was added gene: DRAM2 was added to Retinal disorders. Sources: Expert Review Amber,RetNet,NHS GMS Mode of inheritance for gene: DRAM2 was set to