Retinal disorders
Gene: ZFYVE26The rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 8 Mar 2022, 10:43 a.m. | Last Modified: 8 Mar 2022, 10:43 a.m.
Panel Version: 2.245
Comment on list classification: This gene is associated with a relevant phenotype in OMIM and Gene2Phenotype. There is enough evidence to support a gene-disease association. This gene should be rated Green at the next review.Created: 17 Feb 2021, 4:47 p.m. | Last Modified: 17 Feb 2021, 4:47 p.m.
Panel Version: 2.172
Retinal degeneration can be a feature of this condition.
Sources: Expert listCreated: 15 Oct 2020, 9:49 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Spastic paraplegia 15, autosomal recessive MIM#270700
Publications
Variants in this GENE are reported as part of current diagnostic practice
Tag Q2_21_rating was removed from gene: ZFYVE26.
Source Expert Review Green was added to ZFYVE26. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: zfyve26 has been classified as Amber List (Moderate Evidence).
Tag Q2_21_rating tag was added to gene: ZFYVE26.
Publications for gene: ZFYVE26 were set to 18394578; 14409555; 19805727
Publications for gene: ZFYVE26 were set to 18394578; 14409555
Phenotypes for gene: ZFYVE26 were changed from Spastic paraplegia 15, autosomal recessive MIM#270700 to Spastic paraplegia 15, autosomal recessive OMIM:270700
gene: ZFYVE26 was added gene: ZFYVE26 was added to Retinal disorders. Sources: Expert list Mode of inheritance for gene: ZFYVE26 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ZFYVE26 were set to 18394578; 14409555 Phenotypes for gene: ZFYVE26 were set to Spastic paraplegia 15, autosomal recessive MIM#270700 Review for gene: ZFYVE26 was set to GREEN gene: ZFYVE26 was marked as current diagnostic