Extreme early-onset hypertension

Gene: AGT

Red List (low evidence)

AGT (angiotensinogen)
EnsemblGeneIds (GRCh38): ENSG00000135744
EnsemblGeneIds (GRCh37): ENSG00000135744
OMIM: 106150, Gene2Phenotype
AGT is in 8 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment on list classification: Variants have only been reported in association with susceptibility to essential hypertension and not directly causative
Created: 9 May 2017, 3:11 p.m.
Comment when marking as ready: Associated with phenotype in OMIM, not on G2P.
Created: 9 May 2017, 3:09 p.m.
Comment on list classification: Additional variant reported in Hypertension, essential, susceptibility to 145500
Created: 3 Aug 2016, 8:20 a.m.
Comment on mode of inheritance: biallelic for Renal tubular dysgenesis 267430, multi-factorial for {Hypertension, essential, susceptibility to} 145500
Created: 3 Aug 2016, 7:55 a.m.

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • UKGTN
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • {Hypertension, essential, susceptibility to}, 145500
  • {Preeclampsia, susceptibility to}Renal tubular dysgenesis, 267430
OMIM
106150
Clinvar variants
Variants in AGT
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

2 Feb 2018, Gel status: 1

Set mode of inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for AGT was changed from Other - please specifiy in evaluation comments to Unknown

9 May 2017, Gel status: 1

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

3 Aug 2016, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

Promoted 03/08/2016

3 Aug 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

3 Aug 2016, Gel status: 4

Set publications

Sarah Leigh (Genomics England Curator)

Publications for AGT were set to 24452034

3 Aug 2016, Gel status: 4

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

3 Aug 2016, Gel status: 2

Upload gene information

Sarah Leigh (Genomics England Curator)

AGT was added to Extreme early-onset hypertensionpanel. Sources: UKGTN

3 Aug 2016, Gel status: 1

Set Mode of Inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for AGT was changed to Other - please specifiy in evaluation comments

3 Aug 2016, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for AGT were set to {Hypertension, essential, susceptibility to}, 145500; {Preeclampsia, susceptibility to}Renal tubular dysgenesis, 267430

28 Apr 2015, Gel status: 1

Added New Source

GEL ()

AGT was added to Extreme early-onset hypertensionpanel. Sources: Radboud University Medical Center, Nijmegen