Familial prostate cancer
Gene: BRCA1EnsemblGeneIds (GRCh38): ENSG00000012048
EnsemblGeneIds (GRCh37): ENSG00000012048
OMIM: 113705, Gene2Phenotype
BRCA1 is in 28 panels
2 reviews
Ellen McDonagh (Genomics England Curator)
Spoke to Clare Turnbull about this gene; ok to leave amber at this stage as it is not a clear-cut gene for familial prostate cancer. Only BRCA2 is included on the pertinent germline gene list for the cancer programme.Created: 7 Mar 2017, 1:13 p.m.
Added the 'stratified medicine' tag to indicate the use of PARP inhibitors may be a new therapeutic option for prostate cancer patients with BRCA variants.Created: 26 Jan 2017, 3:41 p.m.
Comment on list classification: Seems to be some controversy over the risk of BRCA1 germline variants and prostate cancer, however a large UK study found a significant increased risk; PMID:22516946.Created: 26 Jan 2017, 3:31 p.m.
Clare Turnbull (Queen Mary University London)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Amber
- Expert list
- Phenotypes
-
- Prostate cancer, MONDO:0008315
- OMIM
- 113705
- Clinvar variants
- Variants in BRCA1
- Penetrance
- Complete
- Publications
-
- 27989354
- 27899188
- 27742670
- 27433846
- 27317574
- 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001)
- 27188668
- 26926928
- 26360800 - no increased risk
- 26236408 - literature review indicating there is conflicting reports
- 22516946
- 28031937
- Panels with this gene
-
- Childhood solid tumours cancer susceptibility
- Familial breast cancer
- Ovarian cancer pertinent cancer susceptibility
- Inherited breast cancer and ovarian cancer
- Cytopenias and congenital anaemias
- Inherited prostate cancer
- Primary immunodeficiency or monogenic inflammatory bowel disease
- DDG2P
- Intellectual disability
- NICE approved PARP inhibitor treatment
- Haematological malignancies cancer susceptibility
- Inherited pancreatic cancer
- Pigmentary skin disorders
- COVID-19 research
- Haematological malignancies for rare disease
- Adult solid tumours for rare disease
- Additional findings health related - CNV analysis adult specific
- GI tract tumours
- Breast cancer pertinent cancer susceptibility
- Familial prostate cancer
- Additional findings health related - adult specific
- Confirmed Fanconi anaemia or Bloom syndrome
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
- Inherited ovarian cancer (without breast cancer)
- Inherited non-medullary thyroid cancer
- Additional findings health related
- Fetal anomalies
History Filter Activity
Removed Tag
Achchuthan Shanmugasundram (Genomics England Curator)Tag stratified-medicine was removed from gene: BRCA1.
Set Phenotypes
Arina Puzriakova (Genomics England Curator)Phenotypes for gene: BRCA1 were changed from to Prostate cancer, MONDO:0008315
panel promoted to version 1
Ellen McDonagh (Genomics England Curator)07/03/2017 - revised and ready to promote to version 1.
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928; 26360800 - no increased risk; 26236408 - literature review indicating there is conflicting reports; 22516946; 28031937
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Amber List (Moderate Evidence).
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Amber List (Moderate Evidence).
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Mode of inheritance for BRCA1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928; 26360800 - no increased risk; 26236408 - literature review indicating there is conflicting reports;22516946
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928; 26360800 - no increased risk;26236408 - literature review indicating there is conflicting reports
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928;26360800 - no increased risk
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668;26926928
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001);27188668
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001).
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846;27317574
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA1 were set to 27989354;27899188;27742670;27433846
Added New Source
Ellen McDonagh (Genomics England Curator)BRCA1 was added to Familial prostate cancerpanel. Sources: Expert list
Created
Ellen McDonagh (Genomics England Curator)BRCA1 was created by ellenmcdonagh