Familial prostate cancer
Gene: BRCA2Added the 'stratified medicine' tag to indicate the use of PARP inhibitors may be a new therapeutic option for prostate cancer patients with BRCA variants.Created: 26 Jan 2017, 3:41 p.m.
Comment on list classification: Expert review green, and a confirmed DD gene for prostate cancer. Strong evidence from PMID: 21952622.Created: 26 Jan 2017, 3:33 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Tag stratified-medicine was removed from gene: BRCA2.
Phenotypes for gene: BRCA2 were changed from male breast cancer and prostate cancer; {Prostate cancer} 176807 to {Prostate cancer}, OMIM:176807
07/03/2017 - revised and ready to promote to version 1.
Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports; 26074382; 21952622;28031937
Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports; 26074382;21952622
Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports;26074382
Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports
Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants;26289772
This gene has been classified as Green List (High Evidence).
Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants
Mode of inheritance for BRCA2 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for BRCA2 were set to male breast cancer and prostate cancer;{Prostate cancer} 176807
Phenotypes for BRCA2 were set to male breast cancer and prostate cancer
Publications for BRCA2 were set to 26360800
BRCA2 was added to Familial prostate cancerpanel. Sources: Expert list
BRCA2 was created by ellenmcdonagh