Familial prostate cancer
Gene: BRCA2EnsemblGeneIds (GRCh38): ENSG00000139618
EnsemblGeneIds (GRCh37): ENSG00000139618
OMIM: 600185, Gene2Phenotype
BRCA2 is in 36 panels
2 reviews
Ellen McDonagh (Genomics England Curator)
Added the 'stratified medicine' tag to indicate the use of PARP inhibitors may be a new therapeutic option for prostate cancer patients with BRCA variants.Created: 26 Jan 2017, 3:41 p.m.
Comment on list classification: Expert review green, and a confirmed DD gene for prostate cancer. Strong evidence from PMID: 21952622.Created: 26 Jan 2017, 3:33 p.m.
Clare Turnbull (Queen Mary University London)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Expert list
- Phenotypes
-
- {Prostate cancer}, OMIM:176807
- OMIM
- 600185
- Clinvar variants
- Variants in BRCA2
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Radial dysplasia
- Limb disorders
- Familial breast cancer
- Ovarian cancer pertinent cancer susceptibility
- Adult solid tumours cancer susceptibility
- Haematological malignancies cancer susceptibility
- DDG2P
- Confirmed Fanconi anaemia or Bloom syndrome
- Inherited pancreatic cancer
- Breast cancer pertinent cancer susceptibility
- Haematological malignancies for rare disease
- Pigmentary skin disorders
- Childhood solid tumours cancer susceptibility
- Inherited breast cancer and ovarian cancer
- Inherited ovarian cancer (without breast cancer)
- Intellectual disability
- Monogenic short stature
- Severe microcephaly
- Cytopenias and congenital anaemias
- COVID-19 research
- Prostate cancer pertinent cancer susceptibility
- Inherited prostate cancer
- Neurofibromatosis Type 1
- Adult solid tumours for rare disease
- Fetal anomalies
- Additional findings health related - CNV analysis adult specific
- Primary immunodeficiency or monogenic inflammatory bowel disease
- GI tract tumours
- Sarcoma susceptibility
- Familial prostate cancer
- Additional findings health related - adult specific
- NICE approved PARP inhibitor treatment
- Familial melanoma
- Childhood solid tumours
- Inherited non-medullary thyroid cancer
- Additional findings health related
History Filter Activity
Removed Tag
Achchuthan Shanmugasundram (Genomics England Curator)Tag stratified-medicine was removed from gene: BRCA2.
Set Phenotypes
Arina Puzriakova (Genomics England Curator)Phenotypes for gene: BRCA2 were changed from male breast cancer and prostate cancer; {Prostate cancer} 176807 to {Prostate cancer}, OMIM:176807
panel promoted to version 1
Ellen McDonagh (Genomics England Curator)07/03/2017 - revised and ready to promote to version 1.
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports; 26074382; 21952622;28031937
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports; 26074382;21952622
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports;26074382
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants; 26289772; 26236408 - literature review indicating there is conflicting reports
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants;26289772
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA2 were set to 26360800; 10398279 - no association found with breast/ovarian cance susceptibility variants
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Mode of inheritance for BRCA2 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Set Phenotypes
Ellen McDonagh (Genomics England Curator)Phenotypes for BRCA2 were set to male breast cancer and prostate cancer;{Prostate cancer} 176807
Set Phenotypes
Ellen McDonagh (Genomics England Curator)Phenotypes for BRCA2 were set to male breast cancer and prostate cancer
Set publications
Ellen McDonagh (Genomics England Curator)Publications for BRCA2 were set to 26360800
Added New Source
Ellen McDonagh (Genomics England Curator)BRCA2 was added to Familial prostate cancerpanel. Sources: Expert list
Created
Ellen McDonagh (Genomics England Curator)BRCA2 was created by ellenmcdonagh