Familial prostate cancer

Gene: BRCA1

Amber List (moderate evidence)

BRCA1 (BRCA1, DNA repair associated)
EnsemblGeneIds (GRCh38): ENSG00000012048
EnsemblGeneIds (GRCh37): ENSG00000012048
OMIM: 113705, Gene2Phenotype
BRCA1 is in 28 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Spoke to Clare Turnbull about this gene; ok to leave amber at this stage as it is not a clear-cut gene for familial prostate cancer. Only BRCA2 is included on the pertinent germline gene list for the cancer programme.
Created: 7 Mar 2017, 1:13 p.m.
Added the 'stratified medicine' tag to indicate the use of PARP inhibitors may be a new therapeutic option for prostate cancer patients with BRCA variants.
Created: 26 Jan 2017, 3:41 p.m.
Comment on list classification: Seems to be some controversy over the risk of BRCA1 germline variants and prostate cancer, however a large UK study found a significant increased risk; PMID:22516946.
Created: 26 Jan 2017, 3:31 p.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • Expert list
Phenotypes
  • Prostate cancer, MONDO:0008315
OMIM
113705
Clinvar variants
Variants in BRCA1
Penetrance
Complete
Publications
  • 27989354
  • 27899188
  • 27742670
  • 27433846
  • 27317574
  • 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001)
  • 27188668
  • 26926928
  • 26360800 - no increased risk
  • 26236408 - literature review indicating there is conflicting reports
  • 22516946
  • 28031937
Panels with this gene

History Filter Activity

27 Dec 2023, Gel status: 2

Removed Tag

Achchuthan Shanmugasundram (Genomics England Curator)

Tag stratified-medicine was removed from gene: BRCA1.

4 Apr 2022, Gel status: 2

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: BRCA1 were changed from to Prostate cancer, MONDO:0008315

7 Mar 2017, Gel status: 2

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

07/03/2017 - revised and ready to promote to version 1.

26 Jan 2017, Gel status: 2

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928; 26360800 - no increased risk; 26236408 - literature review indicating there is conflicting reports; 22516946; 28031937

26 Jan 2017, Gel status: 2

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

26 Jan 2017, Gel status: 2

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

26 Jan 2017, Gel status: 0

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for BRCA1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928; 26360800 - no increased risk; 26236408 - literature review indicating there is conflicting reports;22516946

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928; 26360800 - no increased risk;26236408 - literature review indicating there is conflicting reports

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668; 26926928;26360800 - no increased risk

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001); 27188668;26926928

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001);27188668

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846; 27317574; 27306910 - standardized incidence ratios (SIRs) were used to compare the observed incidence of 20 primary cancer sites to the expected incidence of each cancer based on the calculated risk estimates according to each subject's age, sex, and ethnicity. BRCA1 families had increased SIRs for breast and ovarian cancer (p < .001) and decreased SIRs for kidney, lung, prostate, and thyroid cancer and non-Hodgkin's lymphoma (p < .001).

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354; 27899188; 27742670; 27433846;27317574

26 Jan 2017, Gel status: 0

Set publications

Ellen McDonagh (Genomics England Curator)

Publications for BRCA1 were set to 27989354;27899188;27742670;27433846

27 Jun 2016, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

BRCA1 was added to Familial prostate cancerpanel. Sources: Expert list

27 Jun 2016, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

BRCA1 was created by ellenmcdonagh