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  2. Multiple endocrine tumours
  3. AIP
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Multiple endocrine tumours

Gene: AIP

Green List (high evidence)
AIP (aryl hydrocarbon receptor interacting protein)
EnsemblGeneIds (GRCh38): ENSG00000110711
EnsemblGeneIds (GRCh37): ENSG00000110711
OMIM: 605555, Gene2Phenotype
AIP is in 5 panels

4 reviews

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Katie Snape (South London GMC)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Treena Cranston (Oxford)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Sian Ellard (University of Exeter Medical School)

Green List (high evidence)

An approved UKGTN test
Created: 19 Aug 2015, 9:12 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Created: 19 Aug 2015, 9:12 p.m.

Panel version: 0

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Emory Genetics Laboratory
  • Radboud University Medical Center, Nijmegen
  • Illumina TruGenome Clinical Sequencing Services
  • Eligibility statement prior genetic testing
Phenotypes
  • pituitary tumours
  • Familial Isolated Pituitary Adenomas
  • Pituitary adenoma, growth hormone-secreting, 102200
  • Pituitary adenoma, prolactin-secreting, 600634
  • Pituitary adenoma, ACTH-secreting, 219090
  • Endocrine Cancer
OMIM
605555
Clinvar variants
Variants in AIP
Penetrance
Complete
Panels with this gene

History Filter Activity

1 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

1 Feb 2016, Gel status: 3

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for AIP was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

20 Aug 2015, Gel status: 3

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene AIP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

20 Aug 2015, Gel status: 3

Added New Source

Eik Haraldsdottir (Genomics England)

AIP was added to Multiple endocrine tumourspanel. Source: Emory Genetics Laboratory

20 Aug 2015, Gel status: 2

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene AIP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

20 Aug 2015, Gel status: 2

Added New Source

Eik Haraldsdottir (Genomics England)

AIP was added to Multiple endocrine tumourspanel. Source: Radboud University Medical Center, Nijmegen

20 Aug 2015, Gel status: 1

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene AIP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

20 Aug 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

AIP was added to Multiple endocrine tumourspanel. Source: Illumina TruGenome Clinical Sequencing Services

12 Aug 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

AIP was added to Multiple endocrine tumourspanel. Sources: Eligibility statement prior genetic testing